Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1989-03-02
1991-03-19
Griffin, Ronald W.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, C07K 710
Patent
active
050012231
ABSTRACT:
The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone. The structure of the peptide hormone analogues is exemplified by parathyroid hormone wherein Phe.sup.7 is substituted by NMePhe, D-Phe, desamino Phe, or Met.sup.8 is substituted by NMeMet.
REFERENCES:
patent: 4423037 (1983-12-01), Rosenblatt et al.
patent: 4656250 (1987-04-01), Morita et al.
Biochemistry, 1981, vol. 20, 1981, 7246-7250; "Sulfur-Free PTH Analogues Containing D-Amino Acids; Biological Properties in Vitro or in Vivo".
Caporale Lynn H.
Chorev Michael
Rosenblatt Michael
Caruso Charles M.
Daniel Mark R.
Griffin Ronald W.
Kiessendorf T. D.
Merck & Co. , Inc.
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