Parathyroid hormone and raloxifene for increasing bone mass

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514337, 514257, 514299, 514249, A61K 3138, A61K 3144, A61K 31505, A61K 31495

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active

055103707

ABSTRACT:
The present invention includes a method for increasing bone mass in a subject by administration of PTH and raloxifene. Another aspect of the invention is a method for treating bone loss in a subject by administration of PTH and raloxifene. The invention further provides for a composition of PTH and raloxifene for increasing bone mass in a subject. Another aspect of the invention is a composition of PTH and raloxifene for treatment of bone loss in a subject.

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Jordan et al, Effects of anti-estrogens on bone in castrated and intact female rats; Breast Cancer Research and Treatment; vol. 10; pp. 31-35 (1987).
Gunness-Hey, M. et al, Increased Trabecular Bone Mass in Rats Treated with Human Synthetic Parathyroid Hormone Metab. Bone Dis. & Rel. Res. 5, 177-181 (1984).
Hock, J. M. et al, Human Parathyroid Hormone-(1-34) Increases Bone Mass in Ovariectomized and Orchidectomized Rats* Endocrinology, vol. 122 No. 6 2899-2904 (1988).
Hock, J. M. et al., Comparison of the Anabolic Effects of Synthetic Parathyroid Hormone-Related Protein (PTHrP0 1-34 and PTH 1-34 on Bone in Rats* Endocrinology vol. 125 No. 4 2022-2027 (1989).
Gunness-Hey M. et al., Loss of the Anabolic Effect of Parathyroid Hormone on Bone after Discontinuation of Hormone in Rats, Bone, 10, 447-452 (1989).
Hock et al., Resorption Is Not Essential for the Stimulation of Bone Growth by hPTH-(1-34) in Rats In Vivo, Journal of Bone and Mineral Research vol. 4, No. 3, 449-458 (1989).
Hock J. M., et al. Effects of Continuous and Intermittent Administration and Inhibition of Resorption on the Anabolic Response of Bone to Parathyroid Hormone, Journal of Bone and Mineral Research vol. 7, No. 1 65-72 (1992).
Draper et al.. Effects of raloxifene (LY139481 HC1) on biochemical markers of bone and lipid metabolism in healthy postmenopausal women, Hong Kong, Fourth Int'l'. Symposium on Osteoporosis, Mar. 29, 1993.

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