Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-01-13
1998-12-15
Fitzgerald, David L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530307, 530324, 530399, A61K 3829, A61K 3804
Patent
active
058496955
ABSTRACT:
The present invention relates polypeptide analogs which have agonist or antagonist or tissue selection properties relative to parathyroid hormone (PTH), parathyroid hormone-like protein (PLP) or parathyroid-related protein (PTHrP). The serine amino acid at position 3, the glutamine amino acid at position 6, the histidine amino acid at position 9 or combinations thereof are substituted by other natural or synthetic amino acids. Preferably, a human PTH fragment of about 34 amino acids is sufficient for pharmacological activity. These polypeptides are useful as agonists or antagonists in the treatment of a human being for disease conditions of cancer, osteoporosis, hypercalcemia, or hyperparathyroid disease conditions. The invention also concerns a method of performing certain assays using the modified peptides, and based on the results of the assays falling within preset limits, selecting those modified peptides which shall be useful in the treatment of disease conditions.
REFERENCES:
patent: 3886132 (1975-05-01), Brewer et al.
patent: 4771124 (1988-09-01), Rosenblatt et al.
patent: 4968669 (1990-11-01), Rosenblatt et al.
patent: 5001223 (1991-03-01), Rosenblatt et al.
patent: 5093233 (1992-03-01), Rosenblatt et al.
Schulz et al, Principles of Protein Structure, pp. 14-16, Springer-Verlag (NY), 1979.
Chorev et al, pp. 621-626 in Peptide Chemistry 1987, edited by Shiba et al. (Protein Res. Found., Osaka) 1988.
Cohen Fred E.
Nissenson Robert A.
Strewler Gordon J.
Fitzgerald David L.
Kemmerer Elizabeth C.
The Regents of the University of California
LandOfFree
Parathyroid hormone analogues useful for treatment of osteoporos does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Parathyroid hormone analogues useful for treatment of osteoporos, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Parathyroid hormone analogues useful for treatment of osteoporos will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1457899