Parathyroid hormone analogues substituted at AA 25, 26, 27, and

Details Parathyroid hormone analogues substituted at AA 25, 26, 27, and Parathyroid hormone analogues substituted at AA 25, 26, 27, and

1991-10-10

1994-05-31

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530399, 930 10, 930DIG820, 930DIG821, A61K 3736, C07K 710

Patent

active

053170105

ABSTRACT:
Analogues of bovine and human parathyroid hormone, wherein twenty-fifth, twenty-six and twenty-seventh positions of the natural hormone, Arg-Lys-Lys- each have been substituted with Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val have been found to retain bone cell effect with minimal effects on blood pressure and smooth muscle, including cardiac muscle. It has further been found that this effect can be obtained by using a synthetic PTH containing only the first 34 amino acids of PTH, with substitution at the twenty-fifth, twenty-sixth and twenty-seventh amino acids as described. These analogues of PTH also are effective in the treatment of osteoporosis and other bone diseases.

REFERENCES:
patent: 4086196 (1978-04-01), Tregear
patent: 4771124 (1988-09-01), Rosenblatt
patent: 4833125 (1989-05-01), Neer

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