Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1994-06-20
1996-09-17
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530324, A61K 3829, C07K 14635
Patent
active
055569404
ABSTRACT:
Certain analogues of human parathyroid hormone (hPTH) have been found to be effective for the treatment of osteoporosis, while showing decreased side effects. Analogues showing this effect include all sequences from hPTH-(1-28)-NH.sub.2 to hPTH-(1-31)-NH.sub.2 and all sequences from [Leu.sup.27 ]-hPTH-(1-28)-NH.sub.2 to [Leu.sup.27 ]-hPTH-(1-33)-NH.sub.2. Also included are cyclic analogues cyclo(Lys.sup.26 -Asp.sup.30) [Leu.sup.27 ]-hPTH-(1-34)NH.sub.2 and cyclo (Lys.sup.27 -Asp.sup.30 )-hPTH-(1-34)-NH.sub.2. Analogues in the form of the carboxyl terminal amide are particularly effective.
REFERENCES:
patent: 4086196 (1978-04-01), Tregear
patent: 4771124 (1988-09-01), Rosenblatt et al.
Int. J. Peptide Protein Res., vol. 42, issued 1993, Chorev et al., "Circular dichroism studies of antagonists . . . " pp. 342-345.
Int. J. Peptide Protein Res., vol. 43, issued 1994, Neugebauer et al., "Structure and protein kinase C stimulating activities . . . ", pp. 555-562.
J. Endocr., vol. 74, issued 1977, Visser et al., "Immunological Studies on Parathyroid Hormone . . . ", pp.461-466.
Endocrinology, vol. 108, No. 1, issued 1981, Bringhurst et al., "Bone Collagen Synthesis in vitro . . . ", pp. 103-108.
Neugebauer Witold
Sung Wing L.
Surewicz Witold
Whitfield James F.
Willick Gordon E.
National Research Council of Canada
Russel Jeffrey E.
LandOfFree
Parathyroid hormone analogues for the treatment of osteoporosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Parathyroid hormone analogues for the treatment of osteoporosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Parathyroid hormone analogues for the treatment of osteoporosis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-413963