Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-06-07
2000-08-08
Minnifield, Nita
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 4242651, 424 941, 424 946, 435 691, 435 693, 435 701, 4351723, 4352523, 530350, 530300, 530329, 514 2, 930210, A61K 3900, A61K 3902, C07K 1444, C12N 1530
Patent
active
060998431
ABSTRACT:
The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A.sub.2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
patent: 4879213 (1989-11-01), Fox et al.
patent: 5021342 (1991-06-01), Greene et al.
patent: 5288612 (1994-02-01), Griffin et al.
patent: 5304482 (1994-04-01), Sambrook et al.
Frank et al. Characterization and Cloning of molt associated Excretory-Secretory Proteins of Dirofilaria immitis. Degree date 1992, UMI Dissertation Services.
Lazer et al (1988) Mol. Cell. Biol. vol. 8 (3), 1247-1252.
Burgers et al. (1990) J. Cell Biol. vol. III, 2129-2138.
Roitt et al., 1985, Immunology, pp. 5.4-5.5.
Zwilling et al., 1975, Febs Letters, 60(2):247-249.
Diaz-Sanchez et al., Immunol., 72:297-303, 1991.
Rogers et al., Inf. Immun., 59(4):1442-1447, Apr. 1991.
Abraham, et al., "Passive Transfer of Protective Immunity to Larval Dirofilaria Immitis from Dogs to Balb/C Mice", pp. 254-257, 1991, J. Parasitol., vol. 77(2).
Abraham, et al., "Genetic Control of Murine Immune Responses to Larval Dirofilaria Immitis", pp. 523-528, 1990, J. Parasitol., vol. 76(4).
Abraham, et al., "Dirofilaria Immitis: Molting Process of Third-Stage Larvae", pp. 314-322, 1990, Exp. Parasitol., vol. 70.
Abraham, et al., "Active and Passive Immunization of Mice Against Larval Dirofilaria Immitis", pp. 275-282, 1988, J. Parasitol., vol. 74(2).
Amiri, et al., "The Schistosomatium Douthitti Cerarial Elastase is Biochemically and Structurally Distinct from that of Schistosoma Mansoni," pp. 113-120, 1988, Mol. Biochem. Pharasitol., vol. 28.
Awobuluyi, et al., "Immunureactivity of Cloned Dirofilaria Immitis Proteins in Dogs Following Vaccination with Irradiated Infective Larvae," p. 139, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #150, Dec.
Bianco, et al., "Developmentally Regulated Expression and Secretion of a Polymorphic Antigen by Onchocerca Infective-Stage Larvae", pp. 203-212, 1990, Mol. Biochem. Parasitol., vol. 39.
Blair, et al., "Immunization of Dogs Against Dirofilaria Immitis by Means of Chemically Abbreviated Infections", 1982, Fifth International Congress of Parasitol., Toronto, Canada, Aug.
Boyer, et al., "Differential Antigen Content and Isotype Recognition of O. Volvulvus Antigens from Nodules Removed from Guatemalan Children", p. 169, 1990, 39th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #221, Nov.
Chomczynski, et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", pp. 156-159, 1987, Anal. Biochem., vol. 162.
Coleman, et al., "Use of Implantable Intraperitoneal Diffusion Chambers to Study Bordetella Pertussis Pathogenesis: Growth and Toxin Production in Vivo", pp. 33-39, 1986, J. Infect. Dis., vol. 154(1)m Jul.
Culpepper, et al., "Molecular Characterization of a Dirofilaria Immitis cDNA Encoding a Highly Immunoreactive Antigen", pp. 51-62, 1992, Mol. Biochem. Parasitol., vol. 54.
Dalton, et al., "Thiol Proteases Released in Vitro by Fasciola Hepatica", pp. 161-166, 1989, Mol. Biochem. Parasitol., vol. 35.
Davis, et al., "Purification and Biochemical and Immunologic Characterization of a 25KD Glycoprotein from the Surface of Dirofilaria Immitis Fourth Stage Larvae", p. 256, 1988, 37th Annual Meeting, Am. Soc. Trop. Med. Hyg., Abstract #404.
Delves et al., "Neurosecretory-Like Material in 3rd- and 4th-Stage Dirofilaria Immitis Larvae (Nematoda: Filarioidea)", pp. 99-104, 1989, J. Parasitol., vol. 99.
Denham, "Vaccination Against Filarial Worms Using Radiation-Attenuated Vaccines", pp. 105-111, 1980, Inter. J. Nucl. Med. Biol., vol. 7.
Frank, et al., "Metabolic Labeling of Dirofilaria Immitis Third- and Fourth-Stage Larvae and Their Excretory-Secretory Products", pp. 950-956, 1991, J. Parasitol., vol. 77(6).
Gamble, et al., "Purification of a 44 Kilodalton Protease which Mediates the Ecdysis of Infective Haemonchus Contortus Larvae", pp. 49-58 (1989), Mol. Biochem. Parasitol., vol. 33.
Grieve, et al., "Identification of Dirofilaria Immitis Larval Anitgens with Immunoprophylactic Potential Using Sera from Immune Dogs", pp. 2511-2515, 1992, J. Immunol., vol. 148(8), Apr.
Grieve, "Potential for Immunoprophylaxis Against Heartworm (Dirofilaria Immitis) Infection", pp. 187-190, 1989, Proc. Heartworm Symp.
Grieve, et al., "Induction of Protective Immunity in Dogs to Infection with Dirofilaria Immitis Using Chemically-Abbreviated Infections", pp. 373-379, 1988, Am. J. Trop. Med. Hyg., vol. 39(4).
Grieve, et al., "Epidemiology of Canine Heartworm Infection", pp. 220-246, 1983, Epidem. Rev., vol. 5.
Hewick, et al., "A Gas-Liquid Solid Phase Peptide and Protein Sequenator", pp. 7990-7997, 1981, J. Biol. Chem., vol. 256(15).
Hotez, et al., "Isolation and Characterization of a Proteolytic Enzyme from the Adult Hookworm Ancylostoma Caninum", pp. 7343-7348, 1985, J. Biol. Chem., vol. 260(12).
Ibrahim, et al., "Antigen Shedding from the Surface of the Infective Stage Larvae of Dirofilaria Immitis", pp. 89-97, 1989, J. Parasitol., vol. 99.
Jwo, et al., "Fractionated Sera from Schistosoma Mansoni Infected Patients Confers Passive Protection in Mice", pp. 553-562, 1989, Am. J. Trop. Med. Hyg., vol. 41(5).
Kassis, et al., "Antibody-Dependent Complement-Mediated Killing of Schistosomula in Intraperitoneal Diffusion Chambers in Mice", pp. 1659-1662, 1979, J. Immunol., vol. 123(4), Oct.
Lackey, et al., "Extracellular Proteases of Onchocerca", pp. 176-185, 1989, Exp. Parasitol, vol. 68.
Lal, et al, "Characterization of Stage-Specific Antigens of Infective of the Filarial Parasite Brugia Malayi", pp. 2032-2038, 1988, J. Immunol., vol. 140.
Maki, et al., "Demonstration of Carboxyl and Thiol Protease Activities in Adult Schistosoma Mansoni, Dirofilaria Immitis, Angiostrongylus Cantonensis and Ascaris Suum", pp. 31-37, 1986, J. Helminthol., vol. 60.
McKerow, et al., "Proteinases From Invasive Larvae Of The Trematode Parasite Schistosoma Mansoni Degrade Connective-Tissue And Basement-Membrane Maromolecules", pp. 47-51, 1985, Biochem J., vol. 231.
McKerrow, et al., "Schistosoma Mansoni: Cercarial Degradation of a Radioactively Labeled Collagen Gel", pp. 249-254, 1982, Exp. Parasitol., vol. 53.
McReynolds, et al., "A Large Cuticular Protein from D. Immitis that is Also an Excretory or Secretory Product," pp. 173-174, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #233, Dec.
McReynolds, et al., "Cloning of a Highly Repeated Protein Located in the Gut of Filarial Parasites," p. 295, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #445, Dec.
Mok, et al., "Solubilization of Epicuticular Antigen from Dirofilaria Immitis Third-Stage Larvae", pp. 173-182, 1988, Mol. Biochem. Parasitol., vol. 31.
Noble, et al., "Phylum Nematoda", pp. 256-322, 1982 (See p. 256), Parasitol.: The Biology of Animal Parasites, Section V.
Parab, et al., "Characterization of a Monoclonal Antibody Against Infective Larvae of Brugia Malayi", pp. 169-174, 1988, J. Immunol., vol. 64.
Petralanda, et al., "Studies on a Filarial Antigen With Collagenase Activity", pp. 51-59, 1986, Mol. Biochem. Parasitol., vol. 19.
Philipp, et al., "Biochemical and Immunologic Characterization of a Major Surface Antigen of Dirofilaria Immitis Infective Larvae", pp. 2621-2627, 1986, J. Immunol., vol. 136(7), Apr.
Richer, et al., "Dirofilaria Immitis: Protease Produced By Third- And Fourth-Stage Larvae", pp. 213-222, 1992, Exp. Parasitol., vol. 75.
Robertson, et al., "Toxocara Canis: Proteolytic Enzymes Secreted by the Infective Larvae in Vitro", pp.30-36, 1989, Exp. Parasitol., vol. 69
Frank Glenn R.
Grieve Robert B.
Wisnewski Nancy
Colorado State University Research Foundation
Heska Corporation
Masood Khalid
Minnifield Nita
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