Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1995-06-02
1997-11-11
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4241541, 4241851, 4242661, 530350, 435 691, 435 693, 435 711, A61K 3900, A61K 39002, A61K 3938, C07K 1400
Patent
active
056860803
ABSTRACT:
The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
Abraham, et al., "Passive Transfer of Protective Immunity to Larval Dirofilaria Immitis from Dogs to Balb/C Mice", pp. 254-257, 1991, J. Parasitol., vol. 77(2).
Abraham, et al., "Generic Control of Murine Immune Responses to Larval Dirofilaria Immitis", pp. 523-528, 1990, J. Parasitol., vol. 76(4).
Abraham, et al., "Dirofilaria Immitis: Molting Process of Third-Stage Larvae", pp. 314-322, 1990, Exp. Parasitol., vol. 70.
Abraham, et al., "Active and Passive Immunization of Mice Against Larval Dirofilaria Immitis", pp. 275-282, 1988, J. Parasitol., vol. 74(2).
Amiri, et al., "The Schistosomatium Dourhitri Cerarial Elastase is Biochemically and Structurally Distinct from that of Schistosoma Masoni," pp. 113-120, 1988, Mol. Biochem. Parasitol., vol. 28.
Awobuluyi, et al., "Immunoreactivity of Cloned Dirofilaria Immitis Proteins in Dogs Following Vaccination with Irradiated Infective Larvae," p. 139, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #150, Dec.
Bianco, et al., "Developmentally Regulated Expression and Secretion of a Polymorphic Antigen by Onchooerca Infective-Stage Larvae", pp. 203-212, 1990, Mol. Biochem. Parasitol., vol. 39.
Blair, et al., "Immunization of Dogs Against Dirofilaria immitis by Means of Chemically Abbreviated Infections", 1982, Fifth International congress of Parasitol., Toronto, Canada, Aug.
Boyer, et al., "Differential Antigen Content and Isotype Recognition of O. Volvulvus Antigens from Nodules Removed from Guatemalan Children", p. 169, 1990, 39th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #221, Nov.
Chomczynski, et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", pp. 156-159, 1987, Anal. Biochem., vol. 162.
Coleman, et al., "Use of Implantable Intraperitoneal Diffusion Chambers to Study Bordetella Pertussis Pathogenesis: Growth and Toxin Production in Vivo", pp. 33-39, 1986, J. Infect. Dis., vol. 164(1), July.
Culpepper, et al., "Molecular Characterization of a Dirofilaria Immitis cDNA Encoding a Highly Immunoreactive Antigen", pp. 51-62, 1992, Mol. Biochem. Parasitol., vol. 54.
Dalton, et al., "Thiol Proteases Released In Vitro by Fasciola Hepatica", pp. 161-166, 1989, Mol. Biochem. Parasitol., vol. 35.
Davis, et al., "Purification and Biochemical and Immunologic Characterization of a 25KD Glycoprotein from the Surface of Dirofilaria Immitis Fourth Stage Larvae". pp. 256, 1988, 37th Annual Meeting, Am. Soc. Trop. Med. Hyg., Abstract #404.
Delves, et al., "Neurosecretory-Life Material in 3rd-and 4th-Stage Dirofilaria Immitis Larvae (Nematoda: Filarioidea)", pp. 99-104, 1989, J. Parasitol., vol. 99.
Denham, "Vaccination Against Filarial Worms Using Radiation-Attenuated Vaccines", pp. 105-111, 1980, Inter. J. Nucl. Med. Biol., vol. 7.
Frank, et al., "Metabolic Labelling of Dirofilaria Immitis Third-and Fourth-Stage Larvae and Their Excretory-Secretory Products", pp. 950-956, 1991, J. Parasitol., vol. 77(6).
Gamble, et al., "Purificatrion of a LL Kilodalton Protease which Radiates the Ecolysis of Infective Haemonchus Contortus Larvae", pp. 49-58 (1989), Mol. Biochem. Parasitol., vol. 33.
Grieve, et al., "Identification of Dirofilaria Immitis Larval Antigens with Immunoprophylactic Potential Using Sera from Immune Dogs", pp. 2511-2515, 1992, J. Immunol., vol. 14B(8), April.
Grieve, "Potential for Immunoprophylaxis Against Heartworm (Dirofilaria Immitis) Infection", pp. 187-190, 1989, Proc. Heartworm Symp.
Grieve, et al., "Induction of Protective Immunity in Dogs to Infection with Dirofilaria Immitis Using Chemically-Abbreviated Infections", pp. 373-379, 1988, Am. J. Trop. Med. Hyg., vol. 39(4).
Grieve, et al., "Epidemiology of Canine Heartworm Infection", pp. 220-246, 1983, Epidem. Rev., vol. 5.
Hewick, et al., "A Gas-Liquid Solid Phase Peptide and Protein Sequenator", pp. 7990-7997, 1981, J. Biol. Chem., vol. 256(15).
Hotez, et al., "Isolation and Characterization of a Proteolytic Enzyme from the Adult Hookworm Ancylostoma Caninum", pp. 7343-7348, 1985, J. Biol. Chem., vol. 260(12).
Ibrahim, et al., "Antigen Shedding from the Surface of the Infective Stage Larvae of Dirofilaria Immitis", pp. 89-97, 1989, J. Parasitol., vol. 99.
Jwo, et al., "Fractionated Sera from Schistosoma Mansoni Infected Patients Confers Passive Protection in Mice", pp. 553-562, 1989, Am. J. Trop. Med. Hyg., vol. 41(5).
Kassis, et al., "Antibody-Dependent Complement-Mediated Killing of Schistosomula in Intraperitoneal Diffusion Chambers in Mice", pp. 1659-1662, 1979, J. Immunol., vol. 123(4), Oct.
Lackey, et al., "Extracellular Proteases of Onchocerco", pp. 176-185, 1989, Exp. Parasitol., vol. 68.
Lel, et al, "Characterization of Stage-Specific Antigens of Infective of the Filarial Parasite Brugia Malayi", pp. 2032-2038, 1988, J. Immunol., vol. 140.
Maki, et al., "Demonstration of Carboxyl and Thiol Protease Activities in Adult Schistosoma Mansoni, Dirofilaria Immitis, Antiostrongylus Cantonesis and Ascaris Suum", pp. 31-37, 1986, J. Helminthol., vol. 60.
McKerrow, et al., "Proteinases From Invasive Larvae Of The Trematode Parasite Schistosoma Mansoni Degrade Connective Tissue And Basement-Membrane Macromolecules", pp. 47-51, 1985, Biochem J., vol. 231.
McKerrow, et al., "Schistosoma Mansoni: Cercarial Degradation of a Radioactively Labeled Collagen Gel", pp. 249-254, 1982, Exp. Parasitol., vol. 53.
McReynolds, et al., "A Large Cuticular Protein from D. Immitis that is Also an Excretory or Secretory Product," pp. 173-174, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #233, Dec.
McReynolds, et al., "Cloning of a Highly Repeated Protein Located in the Gut of Filarial Parasites," p. 295, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #445, Dec.
Mok, et al., "Solubilization of Epicuricular Antigen from Dirofilaria Immitis Third-Stage Larvae", pp. 173-182, 1988, Mol. Biochem. Parasitol., vol. 31.
Noble, et al., "Phylum Nematode", pp. 256-322, 1982 (See p. 256), Parasitol.: The Biology of Animal Parasites, Section V.
Parab, et al., "Characterization of a Monoclonal Antibody Against Infective Larvae of Brugia Malayi", pp. 169-174, 1988, J. Immunol., vol. 64.
Petralanda, et al., "Studies on a Filarial Antigen With Collagenase Activity", pp. 51-59, 1986, Mol. Biochem. Parasitol., vol. 19.
Philipp, et al., "Biochemical and Immunologic Characterization of a Major Surface Antigen of Dirofilaria Immitis Infective Larvae", pp. 2621-2627, 1986, J. Immunol., vol. 136(7), April.
Richer, et al., "Dirofilaria Immitis: Proteases Produced By Third-and Fourth-Stage Larvae", pp. 213-222, 1992, Exp. Parasitol., vol. 75.
Robertson, et al., "Toxocara Canis: Proteolytic Enzymes Secreted by the Infective Larvae in Vitro", pp. 30-36, 1989, Exp. Parasitol., vol. 69.
Rogers, "Enzymes in the Exsheathing Fluid of Nematodes and Their Biological Significance", pp. 495-502, 1982, J. Parasitol., vol. 12(6).
Scott, et al., "Surface-Associated Antigens of Second, Third and Fourth Stage Larvae of Dirofilaria Immitis", pp. 339-353, 1990, Acta Tropica, vol. 47.
Sher, et al., "Passive Transfer of Acquired Resistance to Schistoso
Frank Glenn Robert
Grieve Robert B.
Tripp Cynthia Ann
Colorado State University Research Foundation
Heska Corporation
Sidberry Hazel F.
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