Parasitic helminth P39 proteins, and uses thereof

Details Parasitic helminth P39 proteins, and uses thereof Parasitic helminth P39 proteins, and uses thereof

1995-06-06

1999-11-02

Caputa, Anthony C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 530330, 4241841, 4241851, 4241911, 514 2, 435 691, 435 693, 4352523, 4351721, 435 701, 536 231, 536 235, 930210, C07K 1444, C07K 1400, A61K 3900

Patent

active

059773065

ABSTRACT:
The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, and/or antibodies as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
patent: 5021342 (1991-06-01), Green et al.
Abraham, et al., "Passive Transfer of Protective Immunity to Larval Dirofilaria Immitis from Dogs to Balb/C Mice", pp. 254-257, 1991, J. Parasitol., vol. 77(2).
Abraham, et al., "Genetic Control of Murine Immune Responses to Larval Dirofilaria Immitis ", pp. 523-528, 1990, J. Parasitol., vol. 76(4).
Abraham, et al., "Dirofilaria Immitis: Molting Process of Third-Stage Larvae", pp. 314-322, 1990, Exp. Parasitol., vol. 70.
Abraham, et al., "Active and Passive Immunization of Mice Against Larval Dirofilaria Immitis", pp. 275-282, 1988, J. Parasitol., vol. 74(2).
Amiri, et al., "The Schistosomatium Douthitti Cerarial Elastase is Biochemically and Structurally Distinct from that of Schistosoma Mansoni", pp. 113-120, 1988, Mol. Biochem. Parasitol., vol. 28.
Awobuluyi, et al., "Immunureactivity of Cloned Dirofilaria Immitis Proteins in Dogs Following Vaccination with Irradiated Infective Larvae," p. 139, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #150, Dec.
Bianco, et al., "Developmentally Regulated Expression and Secretion of a Polymorphic Antigen by Onchocerca Infective-Stage Larvae", pp. 203-212, 1990, Mol. Biochem. Parasitol., vol. 39.
Blair, et al., "Immunization of Dogs Against Dirofilaria Immitis by Means of Chemically Abbreviated Infections", 1982, Fifth International Congress of Parasitol., Toronto, Canada, Aug.
Boyer, et al., "Differential Antigen Content and Isotype Recognition of O. Volvulvus Antigens from Nodules Removed from Guatemalan Children", p. 169, 1990, 39th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #221, Nov.
Chomczynski, et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Exraction", pp. 156-159, 1987, Anal. Biochem., vol. 162.
Coleman, et al., "Use of Implantable Intraperitoneal Diffusion Chambers to Study Bordetella Pertussis Pathogenesis: Growth and Toxin Production in Vivo", pp. 33-39, 1986, J. Infect. Dis., vol. 154(1), Jul.
Culpepper, et al., "Molecular Characterization of a Dirofilaria Immitis cDNA Encoding a Highly Immunoreactive Antigen", pp. 51-62, 1992, Mol. Biochem. Parasitol., vol. 54.
Dalton, et al., "Thiol Proteases Released in Vitro by Fasciola Hepatica", pp. 161-166, 1989, Mol. Biochem. Parasitol., vol. 35.
Davis, et al., "Purification and Biochemical and Immunologic Characterization of a 25KD Glycoprotein from the Surface of Dirofilaria Immitis Fourth Stage Larvae", p. 256, 1988, 37th Annual Meeting, Am. Soc. Trop. Med. Hyg., Abstract #404.
Delves, et al., "Neurosecretory-Like Material in 3rd- and 4th-Stage Dirofilaria Immitis Larvae (Nematoda: Filarioidea)", pp. 99-104, 1989, J. Parasitol., vol. 99.
Denham, "Vaccination Against Filarial Worms Using Radiation-Attenuated Vaccines", pp. 105-111, 1980, Inter. J. Nucl. Med. Biol., vol. 7.
Frank, et al., "Metabolic Labeling of Dirofilaria Immitis Third- and Fourth-Stage Larvae and Their Excretory-Secretory Products", pp. 950-956, 1991, J. Parasitol., vol. 77(6).
Gamble, et al., "Purification of a 44 Kilodalton Protease which Mediates the Ecdysis of Infective Haemonchus Contortus Larvae", pp. 49-58 (1989), Mol. Biochem. Parasitol., vol. 33.
Grieve, et al., "Identification of Dirofilaria Immitis Larval Anitgens with Immunoprophylactic Potential Using Sera from Immune Dogs", pp. 2511-2515, 1992, J. Immunol., vol. 148(8), Apr.
Grieve, "Potential for Immunoprophylaxis Against Heartworm (Dirofilaria Immitis) Infection", pp. 187-190, 1989, Proc. Heartworm Symp.
Grieve, et al., "Induction of Protective Immunity in Dogs to Infection with Dirofilaria Immitis Using Chemically-Abbreviated Infections", pp. 373-379, 1988, Am. J. Trop. Med. Hyg., vol. 39(4).
Grieve, et al., "Epidemiology of Canine Heartworm Infection", pp. 220-246, 1983, Epidem. Rev., vol. 5.
Hewick, et al., "A Gas-Liquid Solid Phase Peptide and Protein Sequentor", pp. 7990-7997, 1981, J. Biol. Chem., vol. 256(15).
Hotez, et al., "Isolation and Characterization of a Proteolytic Enzyme from the Adult Hookworm Ancylostoma Caninum", pp. 7343-7348, 1985, J. Biol. Chem., vol. 260(12).
Ibrahim, et al., "Antigen Shedding from the Surface of the Infective Stage Larvae of Dirofilaria Immitis", pp. 89-97, 1989, J. Parasitol., vol. 99.
Jwo, et al., "Fractionated Sera from Schistosoma Mansoni Infected Patients Confers Passive in Mice", pp. 553-562, 1989, Am. J. Trop. Med. Hyg., vol. 41(5).
Kassis, et al., "Antibody-Dependent Complement-Mediated Killing of Schistosomula in Intraperitoneal Diffusion Chambers in Mice", pp. 1659-1662, 1979, J. Immunol., vol. 123(4), Oct.
Lackey, et al., "Extracellular Proteases Of Onchocerca", pp. 176-185, 1989, Exp. Parasitol., vol. 68.
Lal, et al, "Characterization of Stage-Specific Antigens of Infective of the Filarial Parasite Brugia Malayi", pp. 2032-2038, 1988, J. Immunol., vol. 140.
Maki, et al., "Demonstration of Carboxyl and Thiol Protease Activities in Adult Schistosoma Mansoni, Dirofilaria Immitis, Angiostrongylus Cantonensis and Ascaris Suum", pp. 31-37, 1986, J. Helminthol., vol. 60.
McKerrow, et al., "Proteinases From Invasive Larvae Of The Trematode Parasite Schistosoma Mansoni Degrade Connective-Tissue And Basement-Membrane Macromolecules", pp. 47-51, 1985, Biochem J., vol. 231.
McKerrow, et al., "Schistosoma Mansoni: Cercarial Degradation of a Radioactively Labeled Collagen Gel", pp. 249-254, 1982, Exp. Parasitol., vol. 53.
McReynolds, et al., "A Large Cuticular Protein from D. Immitis that is Also an Excretory or Secretory Product," pp. 173-174, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #233, Dec.
McReynolds, et al., "Cloning of a Highly Repeated Protein Located in the Gut of Filarial Parasites," p. 295, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #445, Dec.
Mok, et al., "Solubilization of Epicuticular Antigen from Dirofilaria Immitis Third-Stage Larvae", pp. 173-182, 1988, Mol. Biochem. Parasitol., vol. 31.
Noble, et al., "Phylum Nematoda", pp. 256-322, 1982 (See p. 256), Parasitol.: The Biology of Animal Parasites, Section V.
Parab, et al., "Characterization of a Monoclonal Antibody Against Infective Larvae of Brugia Malayi", pp. 169-174, 1988, J. Immunol., vol. 64.
Petralanda, et al., "Studies on a Filarial Antigen With Collagenase Activity", pp. 51-59, 1986, Mol. Biochem. Parasitol., vol. 19.
Philipp, et al., "Biochemical and Immunologic Characterization of a Major Surface Antigen of Dirofilaria Immitis Infective Larvae", pp. 2621-2627, 1986, J. Immunol., vol. 136(7), Apr.
Richer, et al., "Dirofilaria Immitis: Proteases Produced By Third- And Fourth-Stage Larvae", pp. 213-222, 1992, Exp. Parasitol., vol. 75.
Robertson, et al., "Toxocara Canis: Proteolytic Enzymes Secreted by the Infective Larvae in Vitro", pp. 30-36, 1989, Exp. Parasitol., vol. 69.
Rogers, "Enzymes in the Exsheathing Fluid of Nematodes and Their Biological Significance," pp. 495-502, 1982, J. Parasitol., vol. 12(6).
Scott, et al., "Surface-Associated Antigens of Second, Third and Fourth Stage Larvae of Dirofilaria Immitis", pp. 339-353, 1990, Acta Tropica, vol. 47.
Sher, et al., "Passive Transfer of Acquired Resistance to Schistosoma Mansoni in Laboratory Mice", pp. 347-357, 1975, J. Parasitol., vol. 70.
Sim, et al., "Immune Responses in Human Brugia Malayl Infections: Serum Dependent Cell-Mediated Destruction of Infective Larvae in Vitro", pp. 362-370, 1982, Trans. Roy. Soc. Trop. Med. Hyg., vol. 76(3).
Strosberg, et al., "Receptor-Based Assays", pp. 30-

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