Parasitic helminth p22U proteins

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241841, 4241851, 4242651, 530350, 5503871, C07H 2104, A61K 3900

Patent

active

059123370

ABSTRACT:
The present invention relates to an isolated protein comprising a filariid p22U protein. In a preferred embodiment, the filariid p22U protein selectively binds to immune serum which is derived from an animal that is immune to infection by Dirofilaria immitis. Such an animal can be immunized with a composition comprising third and/or fourth stage Dirofilaria immitis larvae. In a preferred embodiment, the filariid p22U protein is a Dirofilaria protein.

REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
Frank Dissertation 1992, Characterization & Cloning of Molt Associated Excretory-Secretary Problems of Dirofilaria Immitis.
Griev et al Pharmaceutical Biotechnology 6:737-68, 1995 (Abstract only).
Freedman et al, The 39th Annual Meeting of the American Society of Tropical Medicine & Hygiene,p.83, Abstract #20.
Mehta et al., The 39th Annual Meeting of the American Society of tropical Medicine & Hygiene p.166, Abstract #214.
Fujita, Japan J. Med. Sci. Biol. 28:139-149, 1975.
Abraham, et al., "Passive Transfer of Protective Immunity to Larval Dirofilaria Immitis from Dogs to Balb/C Mice", pp.254-257, 1991, J. Parasitol., vol. 77(2).
Abraham, et al., "Genetic Control of Murine Immune Responses to Larval Dirofilaria Immitis", pp.523-528, 1990, J. Parasitol., vol. 76(4).
Abraham et al., "Dirofilaria Immitis: Molting Process of Third-Stage Larvae", pp. 314-322, 1990, Exp. Parasitol., vol.70.
Amiri, et al., "The Schistosomatium Douthitti Cerarial Elastase is Biochemically and Structurally Distinct from that of Schistosoma Mansoni", pp.113-120, 1988, Mol. Biochem. parasitol., vol. 28.
Awobuluyi, et al., "Immunureactivity of Cloned Dirofilaria Immitis Proteins in Dogs Following Vaccination with Irradiated Infective Larvae,"p. 139, 1989, 18th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #150, Dec.
Blanco, et al., "Developmentally Regulated Expression and Secretion of a Polymorphic Antigen by Onchocerca Infective-Stage Larvae", pp. 203-212, 1990, Mol. Biochem. Parasitol., vol. 39.
Blair, et al., "Immunization of Dogs Against Dirofilaria Immitis by Means of Chemically Abbreviated Infections", 1982, Fifth International Congress of Parasitol., Toronto, Canada, Aug.
Boyer, et al., "Differential Antigen Content and Isotype Recognition of O. Volvulvus Antigens from Nodules Removed from Guatemalan Children", p. 1990, 39th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #221, Nov.
Chomoczynski et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", pp.156-159, 19987,Anal. Biochem., vol. 162.
Coleman, et al., "Use of Implantable Intraperitoneal Diffusion Chambers to Study Bordetella Pertussis Pathogenesis: Growth and Toxin Production in vivo", pp.33-39, 1986,J. Infect. Dis., vol. 154(1), Jul.
Culpepper, et al., "Molecular Characterization of a Dirofilaria Immitis cDNA Encoding a Highly Immunoreactive Antigen", pp. 51-62, 1992,Mol. Biochem. Parasitol., vol.54.
Dalton, et al., "Thiol Proteases Released in vitro by Fasciola Hepatica", pp.161-166, 1989,Mol. Biochem. Parasitol., vol. 35.
Davis, et al., "Purification and Biochemical and Immunologic Characterization of a 25KD Glycoprotein from the Surface of Dirofilaria Immitis Fourth Stage Larvae", p.256, 1988, 37th Annual Meeting,Am. Soc. Trop. Med. Hyg., Abstract #404.
Delves, et al., "Neurosecretory-Like Material in 3rd-and 4th-Stage Dirofilaria Immitis Larvae (Nematoda: Filarioidea)", pp.99-104, 1989,J. Parasitol., vol. 99.
Denham, "Vaccination Against Filarial Worms Using Radiation-Attenuated Vaccines", pp.105-111, 1980, Inter. J. Nucl. Med. Biol., vol. 7.
Frank, et al., "Metabolic labeling of Dirofilaria Immitis Third-and Fourth-Stage Larvae and Their Excretory Products", pp. 950-956, 1991, J. Parasitol., vol. 77(6).
Gamble, et al., "Purification of a a 44 Kilodalton Protease which Mediates the Ecdysis of Infective Haemonchus Contortus Larvae", pp. 49-58 (1989), Mol. Biochem. Parasitol., vol. 33.
Grieve, et al., "Identification of DIrofilaria Immitis Larval Antigens with Immunoprophylactic Potential Using Sera from Immune Dogs", pp. 2511-25151, 1992, J. Immunol.,vol. 148(8), Apr.
Grieve, "Potential for Immunoprophylaxis Against Heartworm (Dirofilaria Immitis) Infection", pp. 187-190, 1989, Proc. Heartworm Symp.
Grieve, et al., "Induction of Protective Immunity in Dogs to Infection with Dirofilaria Immitis Using Chemically-Abbreviated Infections", pp. 373-379, 1988, Am. J. Trop. Med. Hyg. vol. 39(4).
Grieve, et al., "Epidemiology of Canine Heartworm Infection", pp.220-246, 1983, Epidem. Rev., vol. 5.
Hewick, et al., "A Gas-Liquid Solid Phase Peptide and Protein Sequenator", pp.7990-7997, 1981, J. Biol. Chem., vol. 256(15).
Hotez, et al., "Isolation and Characterization of a Proteolytic Enzyme from the Adult Hookworm Ancylostoma Caninum", pp. 7343-7348, 1985, J. Biol. Chem., vol. 260(12).
Ibrahim, et al., "Antigen Shedding from the Surface of the Infective Stage Larvae of Dirofilaria Immitis", pp. 89-97, 1989, J. Parasitol., vol. 99.
Jwo, et al., "Fractionated Sera from Schistosoma Mansoni Infected Patients Confers Passive Protection in Mice", pp. 553-562, 1989,Am. J. Trop. Med. Hyg., vol. 41(5).
Kassis, et al., "Antibody-Dependent Complement-Mediated Killing of Schistosomula in Intraperitoneal Diffusion Chambers in Mice", pp. 1659-1662, 1979, J.Immunol., vol. 123(4), Oct.
Lackey, et al., "Extracellular Proteases of Onchocerca", pp. 176-185, 1989, Exp. Parasitol., vol. 68.
Lal, et al, "Characterization of Stage-Specific Antigens of Infective of the Filarial parasite Brugia Malayi", pp. 2032-2038, 1988, J. Immunolvol. 140.
Maki, et al.,"Demonstration of Carboxyl and Thiol Protease Activities in Adult Schistosoma Mansoni, Dirofilaria Immitis, Angiostrongylus Cantonensis and Ascaris Suum", pp. 31-37, 1986, J. Helminthol., vol. 60.
McKerrow, et al., "Proteinases From Invasive Larvae Of The Trematode Parasite Schistosoma Mansoni Degrade Connective-Tissue And Basement-Membrane Macromolecules", pp. 47-51, 1985, Biochem J., vol. 231.
McKerrow, et al., "Schistosoma Mansoni: Cercarial Degradation of a Radioactively Labeled Collagen Gel", pp.249-254, 1982, Exp. Parasitol., vol.53.
McReynolds, et al., "A Large Cuticular Protein from D. Immitis that is Also an Excretory or Secretory Product, "pp. 173-174, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #233, Dec.
McReynolds, et al., "Cloning of a Highly Repeated Protein Located in the Gut of Filarial Parasites," p. 295, 1989, 38th Annual Meeting, Am.J. Trop. Med. Hyg., Abstract #445, Dec.
Mok, et al., "Solubilization of Epicuticular Antigen from Dirofilaria Immitis Third-Stage Larvae", pp. 173-182, 1988, Mol. Biochem. Parasitol., vol. 31.
Noble, et al., "Phylum Nematoda", pp. 256-322, 1982 (See page 256), Parasitol.: The Biology of Animal ParasitesSection V.
Parab, et al., "Characterization of a Monoclonal Antibody Against Infective Larvae of Brugia Malayi", pp. 169-174, 1988, J. Immunol., vol. 64.
Petralanda, et al.,"Studies on a Filarial Antigen With Collagenase Activity", pp.51-59, 1986, Mol. Biochem. Parasitol., vo. 19.
Philipp, et al., "Biochemical and Immunologic Characterization of a Major Surface Antigen of Diroflaria Immitis Infective Larvae", pp. 2621-2627, 19886, J. Immunol., vol. 136(7), Apr.
Richer, et al., "Diroflaria Immitis: Proteases Produced By Third-And Fourth-Stage Larvae", pp. 213-222, 1992, Exp. Parasitol., vol. 75.
Robertson et al., "Toxocara Canis: Proteolytic Enzymes Secreted b8y the Infective Larvae in vitro", pp.30-36, 1989, Exp. Parasitol., vol. 69.
Rogers, "Enzymes in the Exsheathing Fluid of Nematodes and Their Biological Significance, " pp. 495-502, 1982, J. Parasitol., vol. 12(6).
Scott, et al., "Surface-Associated Antigens of Second, Third and Fourth Stage Larvae of Dirofilaria Immitis", pp. 339-353, 1990, Acta Tropica, vol.47.
Sher, et al., "Passive Transfer of Acquired Resistance to Schistosoma Mansoni in Laboratory Mice", pp. 347-357, 1975, J. Parasitol., vol. 70.
Sim, et al., "Immune Responses in Human Brugia Malayi Infections: Serum Dependent Cell-Mediated Destruction of Infective Larvae in vitro", pp. 36

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Parasitic helminth p22U proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Parasitic helminth p22U proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Parasitic helminth p22U proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-403399

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.