Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-02
2000-08-08
Housel, James C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 435 693, 435 711, 536 221, 536 231, 536 2432, C07H 2104, C07H 2102, C12P 2106, C12P 7104
Patent
active
061003905
ABSTRACT:
The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
REFERENCES:
patent: 4842999 (1989-06-01), Fuller et al.
Grieve et al Pharmaceutical Biotechnology 6 737-68, 1995, Abstract, 1995.
Suggs et al PNAS 78:6613-6617, 1981.
Dinman et al Experimental Parasitology 71:176-188, 1990.
Yang et al Biochemical & Biophysical Research 212: 1029-1039 (Abstract only), 1995.
Freedman et al The 39th Annual Meeting of the American Society of Tropical Med & Hygien p. 83, Abstract 21, 1990.
Frank Dissertation pp. 100-134 1992.
Rothel et al Immunology & Cell Biology 75:41-46, 1997 (Abstract only.
Parab, et al., "Characterization of a Monoclonal Antibody Against Infective Larvae of Brugia Malayi", pp. 169-174, 1988, J. Immunol., vol. 64.
Petralanda, et al., "Studies on a Filarial Antigen With Collagenase Activity", pp. 51-59, 1986, Mol. Biochem. Parasitol., vol. 19.
Philipp, et al., "Biochemical and Immunologic Characterization of a Major Surface Antigen of Dirofilaria Immitis Infective Larvae", pp. 2621-2627, 1986, J. Immunol., vol. 136(7), Apr.
Richer, et al., "Dirofilaria Immitis: Proteases Produced By Third-- And Fourth-Stage Larvae", pp. 213-222, 1992, Exp. Parasitol., vol. 75.
Robertson, et al., "Toxocara Canis: Proteolytic Enzymes Secreted by the Infective Larvae in Vitro", pp. 30-36, 1989, Exp. Parasitol., vol. 69.
Rogers, "Enzymes in the Exsheathing Fluid of Nematodes and Their Biological Significance," pp. 495-502, 1982, J. Parasitol., vol. 12(6).
Scott, et al., "Surface-Associated Antigens of Second, Third and Fourth Stage Larvae of Dirofilaria Immitis", pp. 339-353, 1990, Acta Tropica, vol. 47.
Sher, et al., "Passive Transfer of Acquired Resistance to Schistosoma Mansoni in Laboratory Mice", pp. 347-357, 1975, J. Parasitol., vol. 70.
Sim, et al., "Immune Responses in Human Brugia Malayi Infections: Serum Dependent Cell-Mediated Destruction of Infective Larvae in Vitro", pp. 362-370, 1982, Trans. Roy. Soc. Trop. Med. Hyg., vol. 76(3).
Strosberg, et al., "Receptor-Based Assays", pp. 30-36, 1991, Current Opin. in Biotech., vol. 2.
Tamashiro, et al., "Proteolytic Cleavage Of lgG and Other Protein Substrates By Dirofilaria Immitis Microfilarial Enzymes", pp. 149-154, 1987, J. Parasitol., vol. 73.
Tanner, et al., "Dipetalonema Viteae (Filarioidea): Development of the Infective Larvae in Micropore Chambers Implanted Into Normal, Infected and Immunized Jirds", pp. 173-174, 1981, Trans. Roy. Soc. Trop. Med. Hyg., vol. 75(1).
Wang, et al., "Parenteral Formulations of Proteins and Peptides: Stability and Stabilizers", pp. S3-S26, 1988, J. Parent. Sci. Tech., vol. 42.
Willadsen, et al., "Immunologic Control of a Parasitic Arthropod, Identification of a Protective Antigen from Boophilus Microplus", pp. 1346-1351, 1989, J. Immunol., vol. 143, Aug.
Young, et al., "Efficient Isolation of Genes by Using Antibody Probes", pp. 1194-1198. 1983, Proc. Natl. Acad. Sci. USA, vol. 80, Mar.
Grieve, et al., "Induction of Protective Immunity in Dogs to Infection with Dirofilaria Immitis Using Chemically-Abbreviated Infections", pp. 373-379, 1988, Am. J. Trop. Med. Hyg., vol. 39(4).
Grieve, et al., "Epidemiology of Canine Heartworm Infection", pp. 200-246, 1983, Epidem. Rev., vol. 5.
Hewick, et al., "A Gas-Liquid Solid Phase Peptide and Protein Sequenator", pp. 7990-7997, 1981, J. Biol. Chem., vol. 256(15).
Hotez, et al., "Isolation and Characterization of a Proteolytic Enzyme from the Adult Hookworm Ancylostoma Caninum", pp. 7343-7348, 1985, J. Biol. Chem., vol. 260(12).
Ibrahim, et al., "Antigen Shedding from the Surface of the Infective Stage Larvae of Dirofilaria Immitis", pp. 89-97, 1989, J. Parasitol., vol. 99.
Jwo, et al., "Fractionated Sera from Schistosoma Mansoni Infected Patients Confers Passive Protection in Mice", pp. 553-562, 1989, Am. J. Trop. Med. Hyg., vol. 41(5).
Kassis, et al., "Antibody-Dependent Complement-Mediated Killing of Schistosomula in Intraperitoneal Diffusion Chambers in Mice", pp. 1659-1662, 1979, J. Immunol., vol. 123(4), Oct.
Lackey, et al., "Extracellular Proteases Of Onchocerca", pp. 176-185, 1989, Exp. Parasitol., vol. 68.
Lal, et al, "Characterization of Stage-Specific Antigens of Infective of the Filarial Parasite Brugia Malayi", pp. 2032-2038, 1988, J. Immunol., vol. 140.
Maki, et al., "Demonstration of Carboxyl and Thiol Protease Activities in Adult Schistosoma Mansoni, Dirofilaria Immitis, Angiostrongylus Cantohensis and Ascaris Suum", pp. 31-37, 1986, J. Helminthol., vol. 60.
McKerrow, et al., "Proteinases From Invasive Larvae Of The Trematode Parasite Schistosoma Mansoni Degrade Connective-Tissue And Basement-Membrane Macromolecules", pp. 47-51, 1985, Biochem J., vol. 231.
McKerrow, et al., "Schistosoma Mansoni: Cercarial Degradation of a Radioactively Labeled Collagen Gel", pp. 249-254, 1982, Exp. Parasitol., vol. 53.
McReynolds, et al., "A Large Cuticular Protein from D. Immitis that is Also an Excretory or Secretory Product," pp. 173-174, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #233, Dec.
McReynolds, et al., "Cloning of a Highly Repeated Protein Located in the Gut of Filarial Parasites," p. 295, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #445, Dec.
Mok, et al., "Solubilization of Epicuticular Antigen from Dirofilaria Immitis Third-Stage Larvae", pp. 173-182, 1988, Mol. Biochem. Parasitol., vol. 31.
Noble, et al., "Phylum Nematoda", pp. 256-322, 1982 (See p. 256), Parasitol: The Biology of Animal Parasites, Section V.
Abraham, et al., "Passive Transfer of Protective Immunity to Larval Dirofilaria Immitis from Dogs to Balb/C Mice", pp. 254-257, 1991, J. Parasitol., vol. 77(2).
Abraham, et al., "Genetic Control of Murine Immune Responses to Larval Dirofilaria Immitis", pp. 523-528, 1990, J. Parasitol., vol. 76(4).
Abraham, et al., "Dirofilaria Immitis: Molting Process of Third-Stage Larvae", pp. 314-322, 1990, Exp. Parasitol., vol. 70.
Abraham, et al., "Active and Passive Immunization of Mice Against Larval Dirofilaria Immitis", pp. 275-282, 1988, J. Parasitol., vol. 74(2).
Amiri, et al., "The Schistosomatium Douthitti Cerarial Elastase is Biochemically and Structurally Distinct from that of Schistosoma Mansoni," pp. 113-120, 1988, Mol. Biochem. Parasitol., vol. 28.
Awobuluyi, et al., "Immunureactivity of Cloned Dirofilaria Immitis Proteins in Dogs Following Vaccination with Irradiated Infective Larvae," p. 139, 1989, 38th Annual Meeting, Am. J. Trop. Med. Hyg., Abstract #150, Dec.
Bianco, et al., "Developmentally Regulated Expression and Secretion of a Polymorphic Antigen by Onchocerca Infective-Stage Larvae", pp. 203-212, 1990, Mol. Biochem. Parasitol., vol. 39.
Blair, et al., "Immunization of Dogs Against Dirofilaria Immitis by Means of Chemically Abbreviated Infections", 1982, Fifth International Congress of Parasitol., Toronto, Canada, Aug.
Boyer, et al., "Differential Antigen Content and Isotype Recognition of O. Volvulvus Antigens from Nodules Removed from Guatemalan Children", p. 169, 1990, 39th Annual meeting, Am. J. Trop. Med. Hyg., Abstract #221, Nov.
Chomczynski, et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", pp. 156-159, 1987, Anal. Biochem., vol. 162.
Coleman, et al., "
Frank Glenn Robert
Grieve Robert B.
Tripp Cynthia Ann
Colorado State University Research Foundation
Heska Corporation
Housel James C.
Swartz Rodney P.
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