Parasitic helminth asparaginase proteins, nucleic acid molecules

Details Parasitic helminth asparaginase proteins, nucleic acid molecules Parasitic helminth asparaginase proteins, nucleic acid molecules

1998-08-25

2000-03-28

Nashed, Nashaat T.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435227, 435229, 435 18, 536 232, A61K 3846, C12N 982

Patent

active

060428252

ABSTRACT:
The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins; antibodies raised against such asparaginase proteins; and compounds that inhibit parasitic helminth asparaginase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

REFERENCES:
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Zhang et al., 1995, "Guinea pig serum L-asparaginase: purification, and immunological relationship to liver L-asparaginase and serum L-asparaginases in other mammals," Comp. Biochem. Pjysiol. 112B:4, pp. 607-612.
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Grantham et al., 1986, Parasitology, vol. 93, 481-493.
Dorner et al., 1993, Genbank Accession No. Q41029.

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