Paraoxonase polypeptides and use therefor

Details Paraoxonase polypeptides and use therefor Paraoxonase polypeptides and use therefor

1997-01-16

1998-08-11

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4351723, 4353201, 4352523, 435325, 536 232, C12N 916, C12N 1555, C12N 1563

Patent

active

057926395

ABSTRACT:
Human serum paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.

REFERENCES:
C. Hasset et al., "Characterization of cDNA Clones Encoding Rabbit and Human Serum Paraoxonase: The Mature Protein Retains Its Signal Sequence", Biochemistry 30(42) 10141-10149, Oct. 1991.
S. Adkins et al., Molecular Basis for the Polymorphic Forms of Human Serum Paraoxonase/Arylesterase: Glutamine or Arginine at Position 191 for the Respective A or B Alloenzymes, Am. J. Hum. Genet. 52: 598-608, 1993.

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