Paraoxonase

Details Paraoxonase Paraoxonase

1994-07-05

1997-05-13

Wax, Robert A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435196, 4351723, 4353201, 4352523, 435365, 435348, 435358, 435419, 536 231, 536 232, 935 14, 935 23, 935 27, 935 56, 935 66, C12N 1555, C12N 1563, C12N 916

Patent

active

056291930

ABSTRACT:
Human paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.

REFERENCES:
S. Adkins et al., "Molecular Basis for the Polymorphic forms of Human Serum Paraoxonase/Arylesterase: Glutamine for Arginie at Position 191, or the Respective A or B Allozymes", Am. J. Hum. Genet. 52:598-608, (1993).
C. E. Furlong et al., "Human and Rabbit Paraoxonases: Purification, Cloning, Sequencing, Mapping and Role of Polymorphism in Organophosphorus Detoxification", Chem.-Biol. Interactions 87:35-48(1993).
La Du, B. N., et al., Studies on Human Serum Paraoxonase Arylesterase, Chem. Biol. Interactions, 87:25-34 (1987).
C. Hassett et al., "Characterization of cDNA Clones Ecoding Rabbit and Human Serum Paraoxonase: The Mature Protein Retains Its Signal Sequence", Biochemistry, 30(42) 10141-10149 (Oct. 1991).
S. Adkins et al., "Recombinant Human Paraoxonase Has both Organophosphatase and Arylesterase Activities", FASEB J. 7(4) A803, (Feb. 1993).
J. Shaw et al., "Nucleotide Sequence of a Novel Arylesterase Gene From Vibrio mimicus and Characterization of the Enzyme Expressed in Escherichia coli", Biochem. J. 298(3)675-680 (Mar. 1994).

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