Parameterization for CT blood flow mapping with xenon gas enhanc

Details Parameterization for CT blood flow mapping with xenon gas enhanc Parameterization for CT blood flow mapping with xenon gas enhanc

1988-11-23

1990-06-05

Smith, Ruth S.

Surgery

Truss

Pad

128659, 128719, A61B 600

Patent

active

049305107

ABSTRACT:
A xenon gas system (B) introduces xenon gas into a patient's blood. The xenon concentration in the patient's blood is monitored (26) periodically as the concentration builds toward a saturation level (32). The absorption data is divided into at least three curved segments (32, 34, 36) each of which are approximated by a curve segment to determine absorption curve characteristics. The amplitude of the saturation curve segment is determined as first characteristic; the slope of the second curve segment is a second characteristic; and an end amplitude and time constant of an exponential third curve segment provide third and fourth characteristics indicative of blood xenon absorption. A CT scanner (A) generates a plurality of time displaced image representations, each of which is subtracted (52) from a reference image (30) to determine difference image representations. Each image representation includes a plurality of pixels that correspond to subregions of a region of interest within the patient. A look-up table (60) is addressed by the absorption curve characteristics and corresponding pixel values to retrieve corresponding partition coefficient, blood flow, and fit or confidence values for each pixel. A video display (76) displays images indicative of the partition coefficient, blood flow rate, or confidence value of the imaged pixels.

REFERENCES:
patent: 3769966 (1973-11-01), Youdin et al.
patent: 4535780 (1985-08-01), Gur et al.
patent: 4718432 (1988-01-01), Kimura et al.
patent: 4793357 (1988-12-01), Lindstrom
"Progress in Cerebrovascular Disease" by Gur, et al., Stroke, vol. 13, No. 6, 1982, pp. 750-758.
"Regional Cerebral Blood Flow Measurement . . ." by Kishore, et al., Journal of Computer Assisted Tomography, Aug. 1984, 619-630.

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