Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1996-08-19
1998-05-12
Scheiner, Laurie
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
436523, 436533, 436537, 436546, 436805, G01N 33553, G01N 33543, G01N 33546, G01N 33542
Patent
active
057504121
ABSTRACT:
An immunoscintillating composition and method of radioimmunoassay is disclosed whereby polymer coated paramagnetic particles and binding agent such as an antibody are associated by chemical or physical means to provide solid scintillating immunoadsorbent particles which are paramagnetic. These particles are capable of selectively binding or retaining radioactive or labeled antigens or ligands and transmitting radioactive energy to a phosphor or photon emitting substance that is bound by chemical or physical means to the particles. Upon binding of the antigens or ligands to the surface of the particles the particles are separated from the unbound components in solution by application of a magnetic field. The luminescence emitted by the phosphor which is attached to the magnetically separated particles is measured by a scintillator counter and is directly proportional to the radioactive energy released by the labeled antigen bound to the antibody. Upon completion of the measurement the paramagnetic particles can be magnetically separated and the labeled antigens or ligands removed for further analysis and the particles recycled for use in other assays.
REFERENCES:
patent: 4650770 (1987-03-01), Liu et al.
Harlow, et al.: Antibodies a laboratory manual: pp. 591-592, 1988.
Kaplan, et al.: Clinicla Chemistry theory, analysis, and correlation: pp. 145-151, 1984.
Erlich Jacob N.
Nelson Brett
Scheiner Laurie
Shea, II Timothy J.
Solid Phase Sciences Corporation
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