Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2007-06-26
2007-06-26
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S009300, C424S009322, C424S009323, C424S009362
Reexamination Certificate
active
10400379
ABSTRACT:
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent. A tether offsetting the chelate from the surface of the particle may optionally contain cleavage sites permitting more facile excretion of the chelated paramagnetic ion.
REFERENCES:
patent: 5064636 (1991-11-01), Li et al.
patent: 5120527 (1992-06-01), Li et al.
patent: 5512294 (1996-04-01), Li et al.
patent: 5571498 (1996-11-01), Cacheris et al.
patent: 5614170 (1997-03-01), Cacheris et al.
patent: 5756069 (1998-05-01), Torchilin et al.
patent: 5780010 (1998-07-01), Lanza et al.
patent: 5804164 (1998-09-01), Elgavish
patent: 5909520 (1999-06-01), Garcia
patent: 6010681 (2000-01-01), Margerum et al.
patent: 6010682 (2000-01-01), Unger et al.
patent: 6045821 (2000-04-01), Garrity et al.
patent: 6088613 (2000-07-01), Unger
patent: 6132764 (2000-10-01), Li et al.
Fossheim, S.L. et al., “Paramagnetic Liposomes as MRI Contrast Agents: Influence of Liposomal Physicochemical Properties on the In Vitro Relaxivity” Magnetic Resonance Imaging 17(1):83-9 (1999).
Grant, C.W. et al., “A Liposomal MRI Contrast Agent: Phosphatidylethanolamine-DTPA” Magnetic Resonance in Medicine 11(2):236-43 (1989).
Kabalka, G.W. et al., “Gadolinium-Labeled Liposomes Containing Amphiphilic Gd-DTPA Derivatives of Varying Chain Length: Targeted MRI Contrast Enhancement Agents for the Liver” Magnetic Resonance Imaging 9(3):373-7 (1991).
Koenig, S.H., “From the Relaxivity of Gd(DTPA)2- To Everything Else” Magnetic Resonance in Medicine 22(2):183-90 (1991).
Miyamoto, M. et al., “Biodistribution of Gadolinium Incorporated in Lipid Emulsions Intraperitoneally Administered for Neutron-Capture Therapy with Tumor-Bearing Hamsters” Biological & Pharmaceutical Bulletin 22(12):1331-40 (1999).
Schwendener, R.A. et al., “A Pharmacokinetic and MRI Study of Unilamellar Gadolinium-, Manganese-, and Iron-DTPA-Stearate Liposomes as Organ-Specific Contrast Agents” Investigative Radiology 25(8):922-32 (1990).
Suga, K. et al., “Potential of Gd-DTPA-Mannan Liposome Particles as Pulmonary Perfusion MRI Contrast Agent: An Initial Animal Study” Investigative Radiology 36(3):136-45 (2001).
Tilcock, C. et al., “The Effect of Lipid Composition on the Relaxivity of Gd-DTPA Entrapped in Lipid Vesicles of Defined Size” Biochimica et Biophysica Acta 1022(2):181-6 (1990).
Tilcock, C., et al., “The Design of Liposomal Paramagnetic MR Agents: Effect of Vesicle Size Upon the Relaxivity of Surface-Incorporated Lipophilic Chelates” Magnetic Resonance in Medicine 27(1):44-51 (1992).
Trubetskoy, V.S. et al., “Controlled Delivery of Gd-Containing Liposomes to Lymph Nodes: Surface Modification May Enhance MRI Contrast Properties” Magnetic Resonance Imaging 13(1):31-7 (1995).
Unger, E.C. et al., “Clearance of Liposomal Gadolinium: In Vivo Decomplexation” Journal of Magnetic Resonance Imaging 1(6):689-93 (1991).
Wisner, E.R. et al., “A Modular Lymphographic Magnetic Resonance Imaging Contrast Agent: Contrast Enhancement with DNA Transfection Potential” Journal of Medicinal Chemistry 40(25):3992-6 (1997).
Lanza Gregory M.
Wickline Samuel A.
Barnes-Jewish Hospital
Jones Dameron L.
Morrison & Foerster / LLP
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