Paramagnetic particles that provide improved relaxivity

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S009322, C424S009323

Reexamination Certificate

active

06869591

ABSTRACT:
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent.

REFERENCES:
patent: 5064636 (1991-11-01), Li et al.
patent: 5120527 (1992-06-01), Li et al.
patent: 5512294 (1996-04-01), Li et al.
patent: 5571498 (1996-11-01), Cacheris et al.
patent: 5614170 (1997-03-01), Cacheris et al.
patent: 5756069 (1998-05-01), Torchilin et al.
patent: 5780010 (1998-07-01), Lanza et al.
patent: 5804164 (1998-09-01), Elgavish
patent: 5909520 (1999-06-01), Garcia
patent: 6010681 (2000-01-01), Margerum et al.
patent: 6010682 (2000-01-01), Unger et al.
patent: 6045821 (2000-04-01), Garrity et al.
patent: 6088613 (2000-07-01), Unger
patent: 6132764 (2000-10-01), Li et al.
Fossheim, S.L. et al., “Paramagnetic Liposomes as MRI Contrast Agents: Influence of Liposomal Physicochemical Properties on the In Vitro Relaxivity” Magnetic Resosance Imaging 17(1):83-9 (1999).
Grant, C.W. et al., “A Liposomal MRI Contrast Agent: Phosphatidylethanolamine-DTPA” Magnetic Resonance in Medicine 11(2):236-43 (1989).
Kabalka, G.W. et al., “Gadolinium-Labeled Liposomes Containing Amphiphilic Gd-DTPA Derivatives of Varying Chain Length: Targeted MRI Contrast Enhancement Agents for the Liver” Magnetic Resonance Imaging 9(3):373-7 (1991).
Koenig, S.H., “From the Relaxivity of Gd(DTPA)2- To Everything Else” Magnetic Resonance in Medicine 22(2):183-90 (1991).
Miyamoto, M. et al., “Biodistribution of Gadolinium Incorporated in Lipid Emulsions Intraperitoneally Administered for Neutron-Capture Therapy with Tumor-Bearing Hamsters” Biological & Pharmaceutical Bulletin 22(12):1331-40 (1999).
Schwendener, R.A. et al., “A Pharmacokinetic and MRI Study of Unilamellar Gadolinium-, Manganese-, and Iron-DTPA-Stearate Liposomes as Organ-Specific Contrast Agents” Investigative Radiology 25(8):922-32 (1990).
Suga, K. et al., “Potential of Gd-DTPA-Mannan Liposome Particles as Pulmonary Perfusion MRI Contrast Agent: An Initial Animal Study” Investigative Radiology 36(3):136-45 (2001).
Tilcock, C. et al., “The Effect of Lipid Composition on the Relaxivity of Gd-DTPA Entrapped in Lipid Vesicles of Defined Size” Biochmica et Biophysica Acta 1022(2):181-6 (1990).
Tilcock, C., et al., “The Design of Liposomal Paramagnetic MR Agents: Effect of Vesicle Size Upon the Relaxivity of Surface-Incorpoated Lipophilic Chelates” Magnetic Resonance in Medicine 27(1):44-51 (1992).
Trubetskoy, V.S. et al., “Controlled Delivery of Gd-Containing Liposomes to Lymph Nodes: Surface Modification May Enhance MRI Contrast Properties” Magnetic Resonance Imaging 13(1):31-7 (1995).
Unger, E.C. et al., “Clearance of Liposomal Gadolinium: In Vivo Decomplexation” Journal of Magnetic Resonance Imaging 1(6):689-93 (1991).
Wisner, E.R. et al., “A Modular Lymphographic Magnetic Resonance Imaging Contrast Agent: Contrast Enhancement with DNA Transfection Potential” Journal of Medicinal Chemistry 40(25):3992-6 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Paramagnetic particles that provide improved relaxivity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Paramagnetic particles that provide improved relaxivity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Paramagnetic particles that provide improved relaxivity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3457992

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.