Paramagnetic oil emulsions as enteric MRI contrast agents

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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424535, 436173, 514558, 514560, 514574, 514943, 514974, 514975, G01N 3100, G01N 2400, A61K 3120, A61K 3119

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050646362

ABSTRACT:
A paramagnetic oil emulsion for enteric administration composed of about 5 to about 30 volume percent oil and about 70 to about 95 volume percent aqueous-based paramagnetic carrier, the aqueous-based paramagnetic carrier having a magnetic resonance contrast effective and less than a toxic amount of at least one water-soluble paramagnetic agent. The paramagetic oil emulsion provides high intensity magnetic resonance signals in the gastro-intestional tract for MRI evaluation of the abdomen and pelvis.

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