Paramagnetic metalloporphyrins as contrast agents for magnetic r

Details Paramagnetic metalloporphyrins as contrast agents for magnetic r Paramagnetic metalloporphyrins as contrast agents for magnetic r

1991-07-22

1993-11-16

Page, Thurman K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424 9, C07D48722

Patent

active

052625320

ABSTRACT:
Porphyrin-complex compounds useful as contrast agents in magnetic resonance imaging (MRI) having the formula ##STR1## where Y is a transition metal such as Fe.sup.III, Cr.sup.III, Mn.sup.III, Mn.sup.II and Cu.sup.II, X is a biologically well-tolerated metal complexing anion such as Cl.sup.-, CF.sub.3 SO.sub.3 or CF.sub.3 COO.sup.- and R is a nonionic water solubilizing moiety.

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S. H. Koenig et al., "The Anomalous Relaxivity of Mn.sup.3+ (TPPS.sub.4)", Magnetic Resonance in Medicine 4, 252-260 (1987).

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