Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1989-07-31
1992-02-11
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 436806, 556 45, 556 57, 556110, 556138, 556148, G01N 2400, G01N 3100, C07F 1300, C07F 1100
Patent
active
050874390
ABSTRACT:
Complexes of a highly paramagnetic polyvalent metal, e.g., a lanthanide such as gadolinium, or of a less paramagnetic metal, e.g., iron, manganese, copper, cobalt, chromium or nickel, with a bisalkylamide of diethylenetriaminepentaacetic acid of the formula: ##STR1## wherein three groups M are hydroxyl groups and the remaining two groups M are NHR groups in which each group R is an alkyl group of the formula --(CH.sub.2).sub.n CH.sub.3 where n is zero or an integer of from 1 to 17, are disclosed. These complexes are useful as magnetic resonance imaging contrast enhancers.
REFERENCES:
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4647447 (1987-03-01), Gries et al.
Minagawa et al., Chem. Abs. 81(16):92489q, (1974).
Grana-Molares et al., Analusis 7(5):249-252, (1979).
Grana-Molares et al., Acta Quim. Compostelana 2(4):127-134, (1978).
Svedaite, T. et al., Liet. TSR Mokslu Akad. Darb. Ser B(4), pp. 59-63, (1983).
Bulman, Ra et al., Naturwlssenschaften 68(9):483-485, (1981).
Hollinden Gary E.
Hollrah Glennon H.
Salutar Inc.
LandOfFree
Paramagnetic metal-diethylenetriamine-pentaacetic acid partial a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Paramagnetic metal-diethylenetriamine-pentaacetic acid partial a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Paramagnetic metal-diethylenetriamine-pentaacetic acid partial a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-780749