Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI age

Details Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI age Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI age

1989-07-13

1992-08-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

534 16, 556 45, 556 57, 556110, 556138, 514492, 514836, 436173, C07F 500, C07F 1300, G01N 3100, G01N 2400

Patent

active

051377110

ABSTRACT:
Novel magnetic resonance imaging agents methods utilize complexes of paramagnetic ions with alkoxyalkylamide deriviatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetyraacetic acid ("EDTA"). These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.
The complexes are represented by the following formula: ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or ##STR2## and M.sup.+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 or 58-70, and a valence number, Z, of 2 or 3; R.sup.1 is --O.sup.- or R.sup.3 --N--R.sup.2, R.sup.2 is --(CH.sub.2 CH.sub.2 O).sub.n --R.sup.4, n is 1-10, R.sup.4 is alkyl or aryl, R.sup.3 is H, R.sup.2, alkyl, hydroxy, alkoxy, cycloalkyl or aryl, wherein Z of the R.sup.1 groups are --O.sup.- and the remainder of the R.sup.1 groups are R.sup.2 -N--R.sup.3 groups.

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Brasch, Robert C., AJR, 142:625-630 (1984).

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