Paramagnetic contrast agents for MR imaging

Details Paramagnetic contrast agents for MR imaging Paramagnetic contrast agents for MR imaging

1986-04-24

1989-08-22

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 536173, 536806, 556 45, 556 51, 556 57, 556 83, 556110, 556118, 556136, 556138, A61K 4900, G01N 3100

Patent

active

048594512

ABSTRACT:
In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through the subject, and after a time interval taking an NMR image of the subject, the improvement which comprises employing as said enhancer a complex of a paramagnetic polyvalent metal and a partial amide and/or ester of diethylenetriaminepentaacetic acid. The complexes are new.

REFERENCES:
patent: 3859337 (1975-02-01), Herz et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay
patent: 4687659 (1987-08-01), Quay
Chemical Abstracts, 81:77423v (1974).
Chemical Abstracts, 90:203450c (1979).
Chemical Abstracts, 101:216407q (1984).
Pykett Ian L., Scientific American, pp. 78-88 (May, 1982).

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