Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic ac

Details Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic ac Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic ac

1994-11-30

1997-03-25

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514492, 514502, 514836, A61B 5055

Patent

active

056141700

ABSTRACT:
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA (diethylenetriaminepentaacetic acid), having a C.sub.10 -C.sub.30 saturated aliphatic group and an hydroxyl group bonded to the nitrogen atom. The emulsions are very stable and therapeutically acceptable for intravenous administration to enhance MRI imaging.

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