Measuring and testing – Liquid analysis or analysis of the suspension of solids in a... – Content or effect of a constituent of a liquid mixture
Reexamination Certificate
2005-12-20
2005-12-20
Cygan, Michael (Department: 2855)
Measuring and testing
Liquid analysis or analysis of the suspension of solids in a...
Content or effect of a constituent of a liquid mixture
C073S061520
Reexamination Certificate
active
06976384
ABSTRACT:
High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomultiplier tube, a charge-coupled device detector, a diode array, and a photodiode array. In certain embodiments, separation columns are microfluidic and integrated into a unitary microfluidic device. The optical path through a detection region is preferably coaxial with the path of eluate flow along a flow axis through a detection region. On-board or off-board detection regions may be provided.
REFERENCES:
patent: 3568692 (1971-03-01), Metzger et al.
patent: 3740158 (1973-06-01), Bellinger et al.
patent: 4823168 (1989-04-01), Kamahori et al.
patent: 4908112 (1990-03-01), Pace
patent: 4989974 (1991-02-01), Anton et al.
patent: 5073345 (1991-12-01), Scott et al.
patent: 5408313 (1995-04-01), Ponstingl et al.
patent: 5444807 (1995-08-01), Liu
patent: 5500071 (1996-03-01), Kaltenbach et al.
patent: 5525405 (1996-06-01), Coverdell et al.
patent: 5637469 (1997-06-01), Wilding et al.
patent: 5731212 (1998-03-01), Gavin et al.
patent: 5882465 (1999-03-01), McReynolds
patent: 5900934 (1999-05-01), Gilby et al.
patent: 5932799 (1999-08-01), Moles
patent: 6074725 (2000-06-01), Kennedy
patent: 6091502 (2000-07-01), Weigl et al.
patent: 6100541 (2000-08-01), Nagle et al.
patent: 6156273 (2000-12-01), Regnier et al.
patent: 6156438 (2000-12-01), Gumm et al.
patent: 6188813 (2001-02-01), Dourdeville et al.
patent: 6264892 (2001-07-01), Kaltenbach et al.
patent: 6289149 (2001-09-01), Druy et al.
patent: 6296771 (2001-10-01), Miroslav
patent: 6318157 (2001-11-01), Corso et al.
patent: 6369893 (2002-04-01), Christel et al.
patent: 6387234 (2002-05-01), Yeung et al.
patent: 6410915 (2002-06-01), Bateman et al.
patent: 6436292 (2002-08-01), Petro
patent: 6437345 (2002-08-01), Bruno-Raimondi et al.
patent: 6441783 (2002-08-01), Dean
patent: 6494230 (2002-12-01), Chow
patent: 6494614 (2002-12-01), Bennett et al.
patent: 6514399 (2003-02-01), Parce et al.
patent: 6524863 (2003-02-01), Abedi
patent: 6532978 (2003-03-01), Müller-Kuhrt et al.
patent: 6537501 (2003-03-01), Holl et al.
patent: 6537506 (2003-03-01), Schwalbe et al.
patent: 6542231 (2003-04-01), Garrett
patent: 6547941 (2003-04-01), Kopf-Sill et al.
patent: 6577793 (2003-06-01), Vaganov
patent: 6581441 (2003-06-01), Paul
patent: 6603546 (2003-08-01), Barbieri et al.
patent: 6613581 (2003-09-01), Wada et al.
patent: 6614030 (2003-09-01), Maher et al.
patent: 6618144 (2003-09-01), Reed
patent: 6623860 (2003-09-01), Hu et al.
patent: 6627433 (2003-09-01), Frazier et al.
patent: 6627446 (2003-09-01), Roach et al.
patent: 6647397 (2003-11-01), Parce
patent: 2002/0041827 (2002-04-01), Yager et al.
patent: 2002/0158022 (2002-10-01), Huang et al.
patent: 2002/0189947 (2002-12-01), Paul et al.
patent: 2002/0199094 (2002-12-01), Strand et al.
patent: 2003/0089663 (2003-05-01), Petro et al.
patent: 2003/0150555 (2003-08-01), Gandhi et al.
patent: 2003/0180711 (2003-09-01), Turner et al.
patent: 2003/0200794 (2003-10-01), Paul
patent: 2003/0230524 (2003-12-01), Soga et al.
patent: 2004/0092702 (2004-05-01), Honma et al.
patent: 1 106 244 (2001-06-01), None
patent: 1 178 309 (2002-02-01), None
patent: WO 95/02178 (1995-01-01), None
patent: WO 97/30347 (1997-08-01), None
patent: WO 98/45693 (1998-10-01), None
patent: WO 99/19717 (1999-04-01), None
patent: WO 99/48599 (1999-09-01), None
patent: WO 00/21659 (2000-04-01), None
patent: WO 00/31528 (2000-06-01), None
patent: WO 00/39573 (2000-07-01), None
patent: WO 00/72970 (2000-12-01), None
patent: WO 01/38865 (2001-05-01), None
patent: WO 02/28532 (2002-04-01), None
patent: WO 02/29106 (2002-04-01), None
patent: WO 02/056006 (2002-07-01), None
Wagner, Knut et al.,An Automated On-Line Multidimensional HPLC System for Protein and Peptide Mapping with Integrated Sample Preparation, “Analytical Chemistry,” vol. 74, No. 4, Feb. 15, 2002, pp. 809-820.
Xu, Rongda et al.,Application of Parallel Liquid Chromatography/Mass Spectrometry for High Throughput Microsomal Stability Screening of Compound Libraries, “Journal of the American Society for Mass Spectrometry,” 2002, 13, 155-165.
Van Pelt, Colleen K. et al.,A Four-Column Parallel Chromatography System for Isocratic or Gradient LC/MS Analyses, “Analytical Chemistry,” vol. 73, No. 3, Feb. 1, 2001, pp. 582-588.
Janiszewski, John S., et al.,A High-Capacity LC/MS System for the Bioanalysis of Samples Generated from Plate-Based Metabolic Screening, “Analytical Chemistry,” vol. 73, No. 7, Apr. 1, 2001, pp. 1495-1501.
Zhang, Bailin et al.,High-Throughput Microfabricated CE/ESI-MS: Automated Sampling from a Microwell Plate, “Analytical CHEmistry,” vol. 73, No. 11, Jun. 1, 2001, pp. 2675-2681.
Tang, Keqi et al.Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity, “Analytical Chemistry,” vol. 73, No. 8, Apr. 15, 2001, pp. 1658-1663.
Yang, Liyu et al.,Evaluation of a Four-Channel Multiplexed Electrospray Triple Quadrupole Mass Spectrometer for the Simultaneous Validation of LC/MS/MS Methods in Four Different Preclinical Matrixes, “Analytical Chemistry,” vol. 73, No. 8, Apr. 15, 2001, pp. 1740-1747.
“LCT with MUX Technology,” Internet document from www.micromass.co.uk/systems/sysorg22.asp, Printed Jul. 19, 2002, date of origin unknown.
Xu, Rongda et al.,High-Throughput Mass-Directed Parallel Purification Incorporating a Multiplexed Single Quadrupole Mass Spectrometer, “Analytical Chemistry,” vol. 74, No. 13, Jul. 1, 2002, pp. 3055-3062.
Fang, Liling et al.,High-throughput liquid chromatography ultraviolet/mass spectrometric analysis of combinatorial libraries using an eight-channel multiplexed electrospray time-of-flight mass spectrometer, “Rapid Communications in Mass Spectrometry,” 2002, 16: 1440-1447.
Svedberg, Malin et al., “Electrospray from a Plastic Chip,”Micro Total Analysis Systems, 2001, 335-336, J.M. Ramsey and A. van den Berg (eds.), Kluwer Academic Publishers, The Netherlands.
Jiang, Yun et al.,Integrated Plastic Microfluidic Devices with ESI-MS for Drug Screening and Residue Analysis, “Analytical Chemistry,” vol. 73, No. 9, May 1, 2001, pp. 2048-2053.
“Multi-Parallel HPLC,” Web document published at: http://www.sepiatec.com/download/phplc.pdf.
God, Ralf et al., “Using multiparallel HPLC for purification in drug discovery from nature,” Web document published at: http://www.iscpubs.com/articles/aln
0112god.pdf.
Tan, Aimin et al.,Chip-Based Solid-Phase Extraction Pretreatment for Direct Electrospray Mass Spectrometry Analysis Using an Array of Monolithic Columns in a Polymeric Substrate, “Analytical Chemistry,” vol. 75, No. 20, Oct. 14, 2003, pp. 5504-5511.
Lin, Yuehe et al., “Microfluidic Devices on Polymer Substrates for Bioanalytical Applications,” Web document published at: www.pnl.gov/microcats/aboutus/publications/ microchemical/Microtechpresentation.pdf, 1999.
Manz, Andreas et al.,Miniaturization of Separation Techniques Using Planar Chip Technology, “Journal of High Resolution Chromatograpy,” vol. 16, Jul. 1993.
Manz, Andreas et al., “Planar Chips Technology for Miniaturization of Separation Systems: A Developing Perspective in Chemical Monitoring,”Advances in Chromatography, vol. 33 (textbook—Marcell Dekker, Inc., New York / Basel / Hong Kong), 1993.
Ceriotti, Laura et al., “Visible and UV Detection Through Square, Deep PDMS Channels,”Micro Total Analysis Systems, pp. 339-340, J.M. Ramsey and A. van den Berg (eds.), 2001 Kluwer Academic Publishers, the Netherlands.
Wolk, Jeffrey et al., “Ultraviolet Absorbance Spectroscopy in a 3-Dimensional Microfluidic Chip,”Micro Total Analysis Systems, pp. J.M. Ramsey and A. van den Berg (eds.), 2001 Kluw
Duong Hau H.
Hobbs Steven E.
Cygan Michael
Gustafson Vincent K.
Intellectual Property / Technology Law
Nanostream, Inc.
LandOfFree
Parallel detection chromatography systems does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Parallel detection chromatography systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Parallel detection chromatography systems will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3501248