Parainfluenza virus vaccine and its preparation

Details Parainfluenza virus vaccine and its preparation Parainfluenza virus vaccine and its preparation

1978-12-29

1980-07-29

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

435237, A61K 3912

Patent

active

042151074

ABSTRACT:
By serially passaging virulent parainfluenza virus in tissue culture prepared from embryonated hens' eggs or human diploid lung fibroblasts, a live, non-pathogenic but antigenic live parainfluenza virus is produced. This virus is useful in preparing a live virus vaccine.

REFERENCES:
Potash et al., J. Infect. Dis. 121 (6):640-647, Jun. 1970, A Mutant of Parainfluenza Type I Virus with Decreased Capacity for Growth at 38.degree. C. and 39.degree. C.
Schieble et al., Chem. Abstr. 80, #66916m (1974), Potential Respiratory Vaccine Strains and Isolation Methods, U.S. Nat. Tech. Inform. Serv. PB Rep. 1973, No. 221701/6, 11 pp.
Tint et al., Chem. Abstr., 78, #128374 (1973), To Provide a Base for Others Against Viral Agents in Respiratory Illness, U.S. Nat. Tech. Inform. Serv. PB Rep. 1972, No. 213497/1, 33 pp.
Straub Chem. Abstr. 82, #90062s (1975) of Ger. Offen. 2,323,847 Living Parainfluenza 3 Vaccine.
Shitikiva et al., Biol. Abstr. 65 (9), 53586, May 1, 1978 of Vopr. Virusol. (4):445-449, 1977, Recd. 1978, The Interfering and Interferon-Inducing Activity of Attenuated and Original Parainfluenza Virus Strains.

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