Parabanic acid derivatives and pharmaceutical compositions there

Details Parabanic acid derivatives and pharmaceutical compositions there Parabanic acid derivatives and pharmaceutical compositions there

1989-07-26

1991-01-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548307, A61K 31415, C07D23396

Patent

active

049854534

ABSTRACT:
Parabanic acid compound of the formula (I): ##STR1## wherein R is hydrogen or a lower alkyl group, X is hydrogen, an alkyl group, a cycloalkyl group, a lower alkylcycloalkyl group, a phenyl group or a phenalkyl group, and n represents an integer of 1 to 4, exhibit excellent aldose reductase inhibitory activity and are useful as drugs for treating or prevention of complications of diabetes.

REFERENCES:
patent: 3766202 (1973-10-01), Singer
Thornber, C., Chem. Soc. Rev., 1979, 8(4), 563-580.

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