Para-terphenyl compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S651000, C514S721000, C568S642000, C568S643000, C544S224000, C544S242000, C544S336000, C544S182000, C546S134000, C546S285000, C548S215000, C548S304400

Reexamination Certificate

active

10704876

ABSTRACT:
The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I):wherein R1–R13are hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is —O—, —CH2—, —NR14— or —S(O)p- and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.

REFERENCES:
patent: 3624142 (1971-11-01), Shen et al.
patent: 4495202 (1985-01-01), Matsumoto et al.
patent: 4594465 (1986-06-01), Kam Ming Chan et al.
patent: 4728670 (1988-03-01), Haslanger et al.
patent: 5417885 (1995-05-01), Suzuki et al.
patent: 5487845 (1996-01-01), Reiffenrath et al.
patent: 5494605 (1996-02-01), Kurihara et al.
patent: 5560864 (1996-10-01), Goulding
patent: 5750051 (1998-05-01), Goulding et al.
patent: 5871665 (1999-02-01), Coates et al.
patent: 5968980 (1999-10-01), Kawashima et al.
patent: WO 93/22397 (1993-11-01), None
patent: 0 769 299 (1997-04-01), None
patent: 2 198 743 (1988-06-01), None
patent: 2 200 912 (1988-08-01), None
patent: 2 240 778 (1991-08-01), None
patent: 43-19935 (1943-08-01), None
patent: 60-13730 (1985-01-01), None
patent: 62-294650 (1987-12-01), None
patent: 5-25145 (1993-02-01), None
patent: 6-507987 (1994-09-01), None
patent: 8-277247 (1996-10-01), None
patent: WO 96/10012 (1996-04-01), None
patent: WO 96-18606 (1996-06-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Akihide, K. :A Prototype Drug for IgE Antibody Synthesis Modulation, Agents and Actions Supplements, 1991, vol. 34, p. 369-378.
Kallitsis, J.K., Synthesis and Characterization of Soluble Aromatic Polyesters Containing Oligophenyl Moieties in the Main Chain., Macromolecules, 1994, vol. 27, p. 4509-4515.
Kakali, F. et al. Synthesis and Characterization of Soluble Aromatic Polyesters Derived from Substituted Terphenyl and Quinquephenyl Diols, J. Polymer Science part A Polymer Chemistry, Jun. 1996, vol. 34, No. 2, p. 1581-1587.
Wagner, Gabriele et al. Ferrocene derivatives containing anthracene linked by spacers, J. Organomet. Chem., Jun. 1996, vol. 516, p. 225-232.
Akira Suzuki et al., New Synthetic Reactions of Organoboron Compounds By Transition Metal Catalysts (in Japanese) The Journal of Synthetic Organic Chemistry Japan, 1993, vol. 51, No. 11, pp. 91 to 100.
Tringali, C. et al. Previously unreported p-terphenyl derivatives with anti-biotic properties from the fruiting bodies ofSarcodon leucopus(Basidiomycetes)., Can. J. Chem., 1987, vol. 65, p. 2369-2372.
Yanagihara et al., “Suppression of IgE Production by IPD-1151T (Suplatast Tosilate), a New Dimethylsulfonium Agent: (2) Regulation of Human IgE Response,” Japan J. Pharmacol. (1993), vol. 61, pp. 31-39.
Loh et al., “Disodium Cromoglycate Inhibits Sμ → Sε Deletional Switch Recombination of IgE Synthesis in Human B Cells,” J. Exp. Med. (1994), vol. 180, pp. 663-671.
Loh et al. “Mechanisms of inhibition of IgE synthesis by nedocromil sodium: Nedocromil sodium inhibits deletional switch recombination in human B cells,” J. Allergy Clin. Immunol. (1996), vol. 97, pp. 1141-1150.
Hasegawa et al. “Novel Naphthalene Derivatives as Inhibitors of Human Immunoglobulin E Antibody Production,” J. Med. Chem. (1997), vol. 40, pp. 395-407.
Li et al., “Novel Terphenyl as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents,” J. Med. Chem. (1996), vol. 39, pp. 1846-1856.
Takahashi et al. “The Structures of Toxic Metabolites ofAspergillus candidus. I. The Compounds A and E, Cytotoxic p-Terphenyls,” Chem. Pharm. Bulletin (1976), vol. 24, No. 4, pp. 613-620.
Vining et al. “3-Hydroxyterphenyllin, A New Metabolite ofAspergillus candidus,” The Journal of Antibiotics (1979), vol. 32, No. 6, pp. 559-564.
Kobayashi et al. “p-Terphenyls with Cytotoxic Activity toward Sea Urchin Embryos,” Agric. Biol. Chem. (1985), Vo. 49, No. 3, pp. 867-868.
STN search results (May 30, 1996 and Jun. 27, 1997).

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