PAR2 modified transgenic mice

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

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800 13, 800 21, 800 25, 435325, 435455, 435461, 435463, C12N 500, C12N 1500, C12N 1509, C12N 1563

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06077990&

ABSTRACT:
Transgenic mice with a non-functional proteinase activated receptor-2 (PAR2) gene are prepared by targeted disruption of the endogenous PAR2 gene. The resulting transgenic mice display a phenotype including a lack of a hypotensive response to administration of the peptide, SLIGRL, and a reduction in carrageenin-induced paw edema compared to wild type mice.

REFERENCES:
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Seamark, R.F., Reprod. Fertil. Dev., 6:653-657, 1994.
Bradley et al., Bio/Technology, 10:534-539, 1992.
Capecchi, M.R., Scientific American, 270:34-41, 1994.
Nystedt et al., Proc. Natl. Acad. Sci. USA, 91:9208-9212, 1994.

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