PAR2 modified transgenic mice

Details PAR2 modified transgenic mice PAR2 modified transgenic mice

1998-08-11

2000-06-20

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 13, 800 21, 800 25, 435325, 435455, 435461, 435463, C12N 500, C12N 1500, C12N 1509, C12N 1563

Patent

active

06077990&

ABSTRACT:
Transgenic mice with a non-functional proteinase activated receptor-2 (PAR2) gene are prepared by targeted disruption of the endogenous PAR2 gene. The resulting transgenic mice display a phenotype including a lack of a hypotensive response to administration of the peptide, SLIGRL, and a reduction in carrageenin-induced paw edema compared to wild type mice.

REFERENCES:
patent: 5175384 (1992-12-01), Krimpenfort et al.
Mullins et al., J. Clin. Invest., 98:S37-S40, 1996.
Seamark, R.F., Reprod. Fertil. Dev., 6:653-657, 1994.
Bradley et al., Bio/Technology, 10:534-539, 1992.
Capecchi, M.R., Scientific American, 270:34-41, 1994.
Nystedt et al., Proc. Natl. Acad. Sci. USA, 91:9208-9212, 1994.

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