Par-2-activating peptide derivative and pharmaceutical...

Details Par-2-activating peptide derivative and pharmaceutical... Par-2-activating peptide derivative and pharmaceutical...

2003-06-10

2009-06-02

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S330000

Reexamination Certificate

active

07541339

ABSTRACT:
The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH2)n—CO—NH-Leu-Ile-Gly-AA1-AA2-CO—R (I) wherein Z represents an aryl group which may or may not have a substituent or a heteroaryl group which may or may not have a substituent; n represents 0, 1 or 2: AA1-AA2represents Lys-Val or Arg-Leu; and R represents —OH or —NH2, and relates to a pharmaceutical composition comprising a peptide derivative represented by the general formula (I) or a salt thereof, and a pharmaceutically acceptable carrier thereof. The peptide derivative is useful as a prophylactic and therapeutic agent of dysfunction of masticatory, dysphagia, dysgeusia, ozostomia, intra-oral cavity dysphoria, intra-oral cavity infections, intra-oral cavity inflammations, dry eye, ectocornea detachment, keratitis, corneal ulcer, conjunctivitis, stomach ulcer, duodenal ulcer, gastritis, diarrhea, enteritis or Sjogren's syndrome.

REFERENCES:
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patent: WO-02/056916 (2002-07-01), None
D'Alessio et al., Bioorganic & Medicinal Chemistry, 7:389-394 (1999).
Santagada et al., Bioorganic & Medicinal Chemistry Letters, 12:21-24 (2002).
Maryanoff et al., Archives of Biochemistry and Biophysics, 386(2):195-204 (2001).
Ferrell et al., “The Journ. Of Clinic. Invest.”, vol. 111, No. 1, pp. 35-41 (2003).

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