Papulacandin derivatives and pharmaceutical compositions contain

Details Papulacandin derivatives and pharmaceutical compositions contain Papulacandin derivatives and pharmaceutical compositions contain

1977-10-21

1981-07-14

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424180, 435 74, 536 4, 536 17R, A61K 3171, C07H 1704

Patent

active

042786657

ABSTRACT:
The new antibiotic "Papulacandin" is obtained by the cultivation of the microorganism Papularia sphaerosperma (Pers.) Hohnel, especially of the strain NRRL 8086, under aerobic conditions in an aqueous nutrient medium. There can also be used mutants of said microorganisms. Papulacandin consists of various components A, B, C, D and E, the more important of which are A and B, whose structures have been elucidated to a great extent: they contain only carbon, hydrogen and oxygen. Papulacandin and its components have a strong anti-fungal action, for instance against Candida albicans, and can be used for combating infections caused by pathogenic fungi.

REFERENCES:
patent: 3945993 (1976-03-01), Schaffner et al.
patent: 3984393 (1976-10-01), Magerlein
patent: 4029769 (1977-06-01), Debono
patent: 4031207 (1977-06-01), Bauer et al.
Ellis, M. B., "Dematious Hyphomycetes", 1971, p. 569.

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