Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1991-08-12
1995-03-14
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
4352351, 435 71, 435 72, 435 721, 435 724, 435 792, 435239, C12N 702
Patent
active
053976967
ABSTRACT:
The present invention relates to a human T-cell line (PNG-1) persistently infected with a Papua New Guinea (PNG) HTLV-I variant and to the infecting virus (PNG-1 variant). Cells of the present invention express viral antigens, type C particles and have a low level of reverse transcriptase activity. The establishment of this cell line, the first of its kind from an individual from Papua New Guinea, makes possible the screening of Melanesian populations using a local virus strain. The present invention also relates to vaccines for use in humans against infection with and diseases caused by HTLV-I and related viruses. The invention further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-I and related viruses.
REFERENCES:
Asher et al: "Ab to HTLV-I in Populations of the Southwestern Pacific" J. of Med Vir 26:339-51 (1988).
Popovic et al "Transformation of Human Umbilical Cord Blood T-cells by HTLV" PNAS 80:5402-6 (1983).
Gallo et al "Comparison of Immunofluorescence, EI, & WB Methods for Detection of Ab to HTLV-1" J. of Clin Microb V26 #8 pp. 1487-1491 (1988).
Garruto Ralph M.
Jenkins Carol
Miller Mark
Nerurkar Vivek R.
Yanagihara Richard
Nucker Christine M.
Stucker Jeffrey
The United States of America as represented by the Department of
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