Papillomavirus vaccine

Details Papillomavirus vaccine Papillomavirus vaccine

2007-01-30

2007-01-30

Mosher, Mary E. (Department: 1648)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S091200, C435S471000, C435S483000, C435S476000, C435S320100, C536S023720

Reexamination Certificate

active

10732345

ABSTRACT:
A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papillomavirus L1 protein or a combination of papillomavirus L1 protein and papillomavirus L2 protein followed by a further step of transfecting a suitable host cell with one or more of the recombinant DNA molecules so that virus like particles (VLPs) are produced within the cell after expression of the L1 or combination of L1 and L2 proteins. The VLPs are also claimed per se as well as vaccines incorporating the VLPs.

REFERENCES:
patent: 4551270 (1985-11-01), Danos et al.
patent: 5045447 (1991-09-01), Minson
patent: 5071757 (1991-12-01), Kreider et al.
patent: 5437951 (1995-08-01), Lowy et al.
patent: 6613557 (2003-09-01), Frazer et al.
patent: WO 91/04330 (1991-04-01), None
patent: WO 93/02184 (1993-02-01), None
Icenogle et al. (Virology 184:101-7, Sep. 1991).
Baker, “Sequence Analysis of Papillomavirus Genomes,”The Papovaviridae, 1987, vol. 2, Salzman and Howley, Eds., Plenum Press.
Baker et al., “Structures of bovine and human papillomaviruses,”Biophys. J., 1991, pp. 1445-1465, vol. 60.
Browne et al., “Analysis of the L1 Gene Product of Human Papillomavirus Type 16 by Expression in a Vaccinia Virus Recombinant,”J. Gen. Virol., 1988, pp. 1263-1273, vol. 69.
Carter et al., “Expression of Human Papillomavirus Proteins in YeastSaccharomyces cerevisiae,” Virology, 1991, pp. 513-521, vol. 182.
Cole et al., “Nucleotide Sequence and Comparative Analysis of the Human Papillomavirus Type 18 Genome,”J. Mol. Biol., 1987, pp. 599-608, vol. 193.
Finch et al., “The Structure of Viruses of the Papilloma-Polyoma Type,”J. Mol. Biol., 1965, pp. 1-12, vol. 13.
Galloway,Journal of the National Cancer Institute, 1994, pp. 474-475, vol. 86, No. 7.
Hagensee et al., “Self-Assembly of Human Papillomavirus Type 1 Capsids by Expression of the L1 Protein Alone or by Coexpression of the L1 and L1 Capside Proteins,”J. Virology, 1993, pp. 315-322, vol. 67.
Kirnbauer et al., “Papillomavirus L1 major capsid protein self-assemblies into virus-like particles that are highly immunogenic,”Proc. Natl. Acad. Sci. USA, 1992, pp. 12180-12184, vol. 89.
Kirnbauer et al., “Efficient Self-Assembly of Human Papillomavirus Type 16 L1 and L1-L2 Into Virus-Like Particles,”J. Virology, 1993, pp. 6929-6936, vol. 36.
Rose et al., “Expression of the full-length products of the human papillomavirus type 6b (HPV-6b) and HPV-11 L2 open reading frames by recombinant baculovirus, and antigenic comparisons with HPV-11 whole virus particles,”J. Gen. Virology, 1990, pp. 2725-2729, vol. 71.
Sambrook et al.,Molecular Cloning: A Laboratory Manual, 2nded. Cold Spring Harbor Laboratory Press, 1989, Table of Contents Only.
Seedorf et al., “Human Papillomavirus Type 16 DNA Sequence,”Virology, 1985, pp. 181-185, vol. 145.
Sterling et al., “Production of Human Papillomavirus Type 16 Virions in a Keratinocyte Cell Line,”J. Virology, 1990, pp. 6305-6307, vol. 64.
Summers et al., “An Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures,”Texas Agricultural Experiment Station Bulletin No. 1555, 1987.
Zhou et al., “Increased Expression of Vaccinia Recombinant HVP 16 L1 and L2 ORF Proteins in Epithelial Cells is Sufficient for Assembly of HPV Virion Like Particles,”J. Gen. Virology, 1990, pp. 2185-2190, vol. 71.
Zhou et al., “Increased antibody responses to human papillomavirus type 16 L1 protein expressed by Recombinant vaccine virus lacking serine protease inhibitor genes,”Chemical Abstracts, Nov. 5, 1990, vol. 13, No. 19.
Zhou et al., “Human Papillomavirus Type 16 Virions Produced by a Recombinant Vaccina Virus,” Abstract from 1991 Papillomavirus Workshop, 1991 (Seattle, WA).
Zhou et al., “Definition of Linear Antigenic Regions of the HPV16 L1 Capsid Protein Using Synthetic Virion-like Particles,”Virology, 1992, pp. 592-599, vol. 189.

Affiliated with

Also associated with

Rating

Papillomavirus vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Papillomavirus vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Papillomavirus vaccine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3795240