Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2000-05-26
2002-12-03
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S186100, C424S199100, C435S069100, C435S320100, C435S069300, C530S300000, C530S350000, C530S403000, C536S023720
Reexamination Certificate
active
06488935
ABSTRACT:
This is a national phase filing of the Application No. PCT/DE98/02379, which was filed with the Patent Corporation Treaty on Aug. 12, 1998, and is entitled to priority of the German Patent Application 197 35 118.2, filed Aug. 13, 1997.
I. FIELD OF THE INVENTION
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. In addition, this invention concerns proteins coded by the papilloma virus genome and antibodies directed against them as well as their use for diagnosis, treatment and vaccination.
II. BACKGROUND OF THE INVENTION
It is known that papilloma viruses infect the epithelium of human beings and animals. Human papilloma viruses (hereinafter referred to as HP viruses) are found in benign epithelial neoplasms, e.g., warts, condylomas in the genital zone, and malignant epithelial neoplasms, e.g., carcinomas of the skin and the uterus. Zur Hausen, H., 1996,
Biochimica et Biophysica Acta
(BBA) 1288:55-78). HP Viruses are also considered for the growth of malignant tumors in the oropharyngeal zone. Zur Hausen, H., 1977,
Curr. Top. Microbiol. Immunol.
78:1-30).
Papilloma viruses have an icosahedral capsid without envelope in which a circular, double-stranded DNA molecule of about 7900 bp is present. The capsid comprises a major capsid protein (11) and a minor capsid protein (L2). Both proteins, coexpressed or L1 expressed alone, result in vitro in the formation of virus-like particles. Kirnbauer et al., 1993,
Journal of Virology
67:6929-6936.
Papilloma viruses cannot be proliferated in monolayer cell culture. Therefore, their characterization is extremely difficult, the detection of papilloma viruses already creating considerable problems. This applies especially to papilloma viruses in carcinomas of the skin.
Thus, it is the object of the present invention to provide a product by which papilloma viruses can be detected, particularly in carcinomas of the skin. Furthermore, a product should be provided to be able to take therapeutic steps against these papilloma viruses.
III. SUMMARY OF THE INVENTION
The present invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. Furthermnore, the present invention concerns proteins coded by the papilloma virus genome and antibodies directed thereagainst as well as the use thereof for diagnosis, treatment and vaccination.
REFERENCES:
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Astori et al., 1998, “Human Papillomavirus are Commonly Found in Normal Skin of Immunocompetent Hosts,” 110:752-755.
Astori et al., 1998, “The papillomaviru found in benign and malignant cutaneous lesions are present in normal skin,”EMBL Sequence Database. Accession No.: AJ000148, clone DL314.
Berkhout et al., 1995, “Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients,”EMBL Sequence Database. Accession No.: L38914, clone ICPX1.
Chan et al., 1992, “Phylogenetic Analysis of 48 Papillomavirus Types and 28 Subtypes and Variants: a Showcase for the Molecular Evolution of DNA Viruses,”Journal of Virology 66(10):5714-5725.
de Villiers et al., 1998, “An interlaboratory study to determine the presence of human papillomavirus DNA in esophageal carcinoma from China,”EMBL Sequence Database. Accession Nos.: AJ000149, clone DL347 and AJ000150, clone DL369.
Delius and Hofmann, 1994, “Primer-Directed Sequencing of Human Papillomavirus Types,”Current Topics in Microbiology and Immunology 186:13-31.
Hopfl et al., 1997, “Human papillomavirus DNA in non-melanoma skin cancers of a renal transplant recipient: detection of a new sequence related to epidermodysplasia verruciformis associated types,”EMBL Sequence Database. Accession No.: U85660, clone RTRX7.
Kirnbauer et al., 1993, “Efficient Self-Assembly of Human Papillomavirus Type 16 L1 and L1-L2 into Virus-Like Particles,”Journal of Virology 67(12):6929-6936.
Pierceall et al., 1991, “Presence fo Human Papilloma Virus Type 16 DNA Sequences in Human Nonmelanoma Skin Cancers,”J. Invest. Dermatol. 97:880-884.
Shamanin et al., 1994, “Development of a broad spectrum PCR assay for papillomaviruses and its application in screening lung cancer biopsies,”Journal of General Virology 75:1149-1156.
Shamanin et al., 1994, “Specific Types of Human Papillomavirus Found in Benign Proliferations and Carcinomas of the Skin in Immunosuppressed Patients,”Cancer Research 54:4610-4613.
Shamin et al., 1996, “Human Papillomavirus Infections in Nonmelanoma Skin Cancers From Renal Transplant Recipients and Nonimmunosuppressed Patients,”Journal of the National Cancer Institute 88(12):802-811.
zur Hausen, 1977, “Human Papillomaviruses and Their Possible Role in Squamous Cell Carcinomas,”Curr. Top. Microbiol. Immunol. 78:1-30.
zur Hausen, 1996, “Papillomavirus infections—a major cause of human cancers,”Biochimica et Biophysica Acta 1288:F55-F78.
De Villiers Zur Hausen Ethel-Michelle
Hausen Harald Zur
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Recht
Pennie & Edmonds LLP
Salimi Ali R.
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