Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
1999-08-05
2002-07-02
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S199100, C435S005000, C435S069100, C435S069300, C435S235100, C435S320100, C536S023720, C530S350000, C530S324000
Reexamination Certificate
active
06413522
ABSTRACT:
I. FIELD OF THE INVENTION
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. In addition, this invention concerns proteins coded by the papilloma virus genome and antibodies directed against them as well as their use for diagnosis, treatment and vaccination.
II. BACKGROUND OF THE INVENTION
It is known that papilloma viruses infect the epithelium of human beings and animals. Human papilloma viruses (hereinafter referred to as HP viruses) are found in benign epithelial neoplasms, e.g. warts, condylomas in the genital zone, and malignant epithelial neoplasms, e.g. carcinomas of the skin and the uterus (zur Hausen, 1996,
Biochimica et Biophysica Acta
(
BBA
) 1288:55-78). HP viruses are also considered for the growth of malignant tumors in the oropharyngeal zone (zur Hausen, 1977
, Curr. Top. Microbiol. Immunol.
78:1-30).
Papilloma viruses have an icosahedral capsid without envelope in which a circular, double-stranded DNA molecule of about 7900 bp is present. The capsid comprises a major capsid protein (L1) and a minor capsid protein (L2). Both proteins, coexpressed or L1 expressed alone, result in vitro in the formation of virus-like particles (Kirnbauer et al., 1993,
Journal of Virology
67:6929-6936).
Papilloma viruses cannot be proliferated in monolayer cell culture. Therefore, their characterization is extremely difficult, the detection of papilloma viruses already creating considerable problems. This applies especially to papilloma viruses in carcinomas of the skin.
Thus, it is the object of the present invention to provide a product by which papilloma viruses can be detected, particularly in carcinomas of the skin. Furthermore, a product should be provided to be able to take therapeutic steps against these papilloma viruses.
According to the invention, this is achieved by providing the subject matters in the claims.
III. SUMMARY OF THE INVENTION
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. Furthermore, this invention concerns proteins coded by the papilloma virus genome and antibodies directed thereagainst as well as the use thereof for diagnosis, treatment and vaccination.
REFERENCES:
patent: WO 95/30754 (1995-11-01), None
patent: WO 97/04099 (1997-02-01), None
de Villiers et al., 1997, “Prevailing papillomaviurs types in non-melanoma carcinomas of the skin in renal allograft recipients,”International Journal of Cancer 73(3):356-361.
Hagensee et al., 1993, “Self-assembly of human papillomavirus type 1 capsids by expression of the L1 protein alone or by coexpression of the L1 and L2 capsid proteins,”Journal of Virology 67(1):315-322.
Kirnbauer et al., 1993, “Effecient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles,”Journal of Virology 67(12):6929-6936.
zur Hausen, 1977, “Human papillomavirus and their possible role in squamous cell carcinomas,”Curr. Top. Microbiol. Immunol. 78:1-30.
zur Hausen, 1996, “Papillomavirus infections—a major cause of human cancers,”Biochimica et Biophysica Acta 1288(2):F55-F78.
Benton Claire
De Villiers-Zur Hausen Ethel-Michele
Hausen Harald Zur
Lavergne Donna
Deutsches Krebsforschungszentrum Stiftung des Offentlichen Recht
Pennie & Edmonds LLP
Salimi Ali R.
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