Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-04-17
2007-04-17
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S235100
Reexamination Certificate
active
11060034
ABSTRACT:
The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
REFERENCES:
patent: 6878541 (2005-04-01), Qiao et al.
patent: WO 99/13056 (1999-03-01), None
Touze et al (Nucleic Acid Research, 1998, vol. 26, No. 5, pp. 1317-1323).
Huang Yujun
Liu Jianzhong
Qiao Liang
Shi Wei
Henneman & Associates PLC
Henneman, Jr. Larry E.
Loyola University Chicago
Salimi Ali R.
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