Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-04-12
2005-04-12
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C435S235100, C435S239000
Reexamination Certificate
active
06878541
ABSTRACT:
The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudo-viruses (VLPs with plasmids inside). Oral administration of the pseudo-viruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudo-virus induces stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
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Huang Yujun
Liu Jianzhong
Qiao Liang
Shi Wei
Henneman & Saunders
Henneman, Jr. Larry E.
Salimi Ali R.
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