Papaverine thienyl-carboxylates and medicaments containing them

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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260285, A61K 31485, C07D21720

Patent

active

040556484

ABSTRACT:
Novel salts of papaverine are constituted by the thienyl-carboxylates of papaverine notably papaverine thienyl-2-carboxylate. A papaverine thienyl-carboxylate is prepared by reacting papaverine base with the corresponding thiophene carboxylic acid. The medicaments comprise, as active principle, a papaverine thienyl-carboxylate associated with a solid excipient making it suitable for administration by the oral route, or with an excipient making it suitable for administration by the rectal route. The medicament, is useful for the treatment of hyperspasmodicity of the smooth muscles, and for the treatment of vascular disorders, notably due to senescence, more particularly those bringing into action cortical reactivity.

REFERENCES:
patent: 2027722 (1936-01-01), Diehl
patent: 2507086 (1950-05-01), Baizer
patent: 3823234 (1974-07-01), Mauvernay

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