Pantropic retroviral vectors for gene transfer in mollusks

Details Pantropic retroviral vectors for gene transfer in mollusks Pantropic retroviral vectors for gene transfer in mollusks

1997-04-18

1999-10-19

Stanton, Brian R.

Multicellular living organisms and unmodified parts thereof and

Method of making a transgenic nonhuman animal

Via retrovirus

800 8, 800 13, C12N 500, C12N 1500

Patent

active

059692111

ABSTRACT:
A method for introducing foreign nucleic acid sequences into marine mollusks. A pantropic retroviral vector containing a foreign gene sequence is introduced into fertilized mollusk embryos by electroporation. The gene sequence becomes integrated into the host DNA and encodes a functional protein product. This method has implications in the introduction of disease-resistance and growth-accelerating genes into mollusks.

REFERENCES:
patent: 5675061 (1997-10-01), Powers et al.
Chen et al. Production of transgenic dwarf surfclams, Mulinia lateralis, with pantropic retroviral vectors. Appeared in the Journal of Shellfish Research. Presented at the Annual Meeting of the National Shellfisheries Association, Baltimore, MD., Downl, Apr. 18, 1996.

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