Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-05-03
2011-05-03
Stucker, Jeffrey (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008400, C514S021200, C530S350000
Reexamination Certificate
active
07935671
ABSTRACT:
Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
REFERENCES:
patent: 5939534 (1999-08-01), Inoue et al.
patent: 6656465 (2003-12-01), Clary et al.
patent: 7144983 (2006-12-01), Urfer et al.
patent: 7528233 (2009-05-01), Urfer et al.
patent: WO 92/02620 (1992-02-01), None
patent: WO 93/18066 (1993-09-01), None
patent: WO 93/25684 (1993-12-01), None
patent: WO 94/12539 (1994-06-01), None
Barde et al., “Purification of a New Neurotrophic Factor From Mammalian Brain”EMBO Journal1(5):549-553 (1982).
Barde, Y. A., “Trophic Factors and Neurone Survival”Neuron.2:1525-1534 (1989).
Berkemeier et al., “Neurotrophin-5: A Novel Neurotrophic Factor That Activated trk and trkB”Neuron7:857-866 (Nov. 1991).
Bothwell, M., “Keeping Track of Neurotrophin Receptors”Cell65:915-918 (Jun. 14, 1991).
Burton et al., “Activity and Biospecificity of Proteolized Forms and Dimeric Combinations of Recombinant Human and Murine Nerve Growth Factor”J. Neurochem. 59(5):1937-1945 (1992).
Camerini et al ., “The T Cell Activation Antigen CD27 is a Member of the Nerve Growth Factor/Tumor Necrosis Factor Receptor Gene Family”J. Immunol. 147(9):3165-3169 (Nov. 1, 1991).
Chao, M. V., “Neurotrophin Receptors: A Window into Neuronal Differentiation”Neuron9:583-593 (Oct. 1992).
Connolly et al., “Pit Formation and Rapid Changes in Surface Morphology of Sympathetic Neurons in Response to Nerve Growth Factor”Journal of Cell Biology90:176-180 (Jul. 1981).
Cordon-Cardo et al., “The trk Tyrosine Protein Kinase Mediated the Mitogenic Properties of Nerve Growth Factor and Neurotrophin-3”Cell66:173-183 (Jul. 12, 1991).
Davies et al., “Neurotrophin-4/5 is a Mammalian-specific Survival Factor for Distinct Populations of Sensory Neurons”J. Neuroscience13(11):4961-4967 (Nov. 1993).
Davies et al ., “The Response of Chick Sensory Neurons to Brain-Derived Neurotrophic Factor”Neuroscience6(7):1897-1904 (Jul. 1986).
Davies, A. M., “Role of neurotrophic factors in development”Trends in Geneticspp. 139-143 (1988).
Ernfors et al., “Molecular Cloning and Neurotrophic Activities of a Protein With Structural Similarities to Nerve Growth Factor: Developmental and Topographical expression in the brain”Proc. Natl. Acad. Sci. USA87:5454-5458 (Jul. 1990).
Halegoua et al., “Nerve Growth Factor Mediates Phosphorylation of Specific Proteins”Cell22:571-581 (Nov. 1980).
Hallbook et al., “Evolutionary Studies of the Nerve Growth Factor Family Reveal a Novel Member Abundantly Expressed in Xenopus Ovary”Neuron6:845-858 (May 1991).
Hefti, Franz, “Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Pimbrial Transections”J. of Neuroscience6(8):2155-2162 (Aug. 1986).
Hohn et al., “Identification and Characterization of a Novel Member of the Nerve Growth Factor/Brain-derived Neurotrophic Factor Family”Nature344:339-341 (Mar. 22, 1990).
Hory-Lee et al., “Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture”Proc. Natl. Acad. Sci. USA90:2613-2617 (Apr. 1993).
Ibanez et al., “Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF”EMBO Journal10(8):2105-2110 (1991).
Ibanez et al., “Disruption of the Low Affinity Receptor-Binding Site in NGF Allows Neuronal Survival and Differentiation by Binding to the trk Gene Product”Cell69:329-341 (Apr. 17, 1992).
Ibanez et al., “An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of multifunctional pan-neurotrophin”EMBO Journal12(6):2281-2293 (1993).
Ip et al., “Mammalian Neurotrophin-4: Structure, Chromosomal Localization, Tissue Distribution, and Receptor Specificity”Proc. Natl. Acad. Sci. USA89:3060-3064 (Apr. 1992).
Ip et al., “Similarities and Differences in the Way Neurotrophins Interact with the Trk Receptors in Neuronal and Nonneuronal Cells”Neuron10:137-149 (Feb. 1993).
Johnson et al., “Expression and Structure of the Human NGF Receptor”Cell47:545-554 (Nov. 21, 1986).
Jones et al., “Molecular Cloning of a Human Gene That is a Member of the Nerve Growth Factor Family”Proc. Natl. Acad. Sci. USA87:8060-8064 (1990).
Kahle et al., “The Amino Terminus of Nerve Growth Factor is Involved in the Interaction with the Receptor Tyrosine Kinase p140trkA-”Journal of Biological Chemistry267(32):22707-22710 (Nov. 15, 1992).
Kaisho et al., “Cloning and expression of a cDNA encoding a novel human neurotrophic factor”FEBS Letters266(1,2):187-191 (Jun. 1990).
Kalcheim et al., “Neurotrophin 3 is a mitogen for cultures neural crest cells”Proc. Natl. Acad. USA89:1661-1665 (Mar. 1992).
Kaplan et al., “The trk Proto-Oncogene Product: A Signal Transducing Receptor for Nerve Growth Factor”Science252:554-558 (Apr. 26, 1991).
Kaplan et al., “Tyrosine Phosphorylation and Tyrosine Kinase Activity of the trk Proto-oncogene Product Induced by NGF”Nature350:158-160 (Mar. 14, 1991).
Klein et al., “The trk Proto-Oncogene Encodes a Receptor for Nerve Growth Factor”Cell65:119-197 (Apr. 5, 1991).
Klein et al., “The trkB Tyrosine Protein Kinase is a Receptor for Brain-Derived-Neurotrophic Factor and Neurotrophin-3”Cell66:395-403 (Jul. 26, 1991).
Klein et al., “The trkB Tyrosine Protein Kinase is a Receptor for Neurotrophin-4”Neuron8:947-956 (May 1992).
Klein et al., “trkB, A Novel Tyrosine Protein Kinase Receptor Expressed During Mouse Neural Development”EMBO Journal8(12):3701-3709 (1989).
Korsching, Sigrun, “The role of nerve growth factor in the CNS”TINSpp. 570-573 (Nov./Dec. 1986).
Lamballe et al., “trkC, a New Member of the trk Family of Tyrosine Protein Kinases, is a Receptor for Neurotrophin-3”Cell66:967-979 (Sep. 6, 1991).
Leibrock et al., “Molecular Cloning and Expression of Brain-derived Neurotrophic Factor”Nature341:149-152 (Sep. 14, 1989).
Levi-Montalcini et al., “Nerve Growth Factor”Physiol. Rev. 48(3):535-569 (Jul. 1968).
Loetscher et al., “Molecular Cloning and Expression of the Human 55 kd Tumor Necrosis Factor Receptor”Cell61:351-359 (Apr. 20, 1990).
Maisonpierre et al., “Neurotrophin-3: A Neurotrophic Factor Related to NGF and BDNF”Science247:1446-1451 (Mar. 23, 1990).
Maisonpierre et al., “NT-3, BDNF, and NGF in the Developing Rat Nervous System: Parallel as well as Reciprocal Patterns of Expression”Neuron5:501-509 (Oct. 1990).
Mallett et al., “Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes—a molecule related to nerve growth factor receptor”EMBO Journal9(4):1063-1068 (1990).
Martin-Zanca et al., “Molecular and Biochemical Characterization of the Human trk Proto-Oncogene”Molecular&Cellular Biology9(1):24-33 (Jan. 1989).
Radeke et al., “Gene transfer and molecular cloning of the rat nerve growth factor receptor”Nature325:593-597 (Feb. 12, 1987).
Reidhaar-Olson et al., “Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences”Science241:53-57 (Jul. 1, 1988).
Rosenthal et al., “Primary Structure and Biological Activity of a Novel Human Neurotrophic Factor”Neuron4:767-773 (May 1990).
Schall et al., “Molecular Cloning and Expression of a Receptor for Human Tumor Necrosis Factor”Cell61:361-370 (Apr. 20, 1990).
Shelton et al., “Expression of the β-nerve growth factor gene correlates with t
Presta Leonard G.
Urfer Roman
Winslow John W.
Arnold & Porter LLP
Elliott Jennifer L.
Fox James A.
Genentech Inc.
Gucker Stephen
LandOfFree
Pantropic neurotrophic factors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pantropic neurotrophic factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pantropic neurotrophic factors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2679226