Pancreatic islet cell growth factors

Details Pancreatic islet cell growth factors Pancreatic islet cell growth factors

2005-11-22

2005-11-22

Falk, Anne-Marie (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S375000, C435S395000, C435S398000, C435S402000

Reexamination Certificate

active

06967100

ABSTRACT:
The present invention relates generally to growth factors and more particularly to growth factors which are capable of stimulating or otherwise facilitating formation of insulin-secreting cells. The identification of these growth factors permits the development of protocols to culture cells in vitro for transplantation into mammalian and in particular human subjects with insulin-dependent type 1 diabetes or related conditions. It is further contemplated that the endogenous expression of growth factors required for the development of insulin-producing cells may be manipulated in vivo, by the appropriate administration of agents including genetic agents capable of regulating the expression of growth factors in pancreatic duct epithelial cells. The growth factors ray also be administered to subjects with type 1 diabetes to stimulate the proliferation and differentiation of pancreatic cells into insulin-secreting cells. The present invention also provides modulators of growth factor-mediated pancreatic cell differentiation. Such modulators are useful in the treatment inter alia of β cell tumors and/or pancreatic cancer.

REFERENCES:
patent: 4935000 (1990-06-01), Dudek
Stem Cells: Scientific Progress and Future Research Directions. Department of Health and Human Services. Jun. 2001. http://www.nih.gov
ews/stemcell/scireport.htm.
Jiang et al. Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J Cell Sci. Feb. 15, 2002;115(Pt 4):753-60.
Kerr-Conte et al. Ductal cyst formation in collagen-embedded adult human islet preparations. A means to the reproduction of nesidioblastosis in vitro. Diabetes, Aug. 1996;45(8):1108-14.
Bancroft J.D. et al.,Theory and Practice of Histological Techniques(Churchill Livingstone, Edinburgh), 188-190.
Uehara Y. et al., “Phenotypic Change From Transformed To Normal Induced By Benzoquinonoid Ansamycins Accompanies Inactivation of p60srcIn Rat Kidney Cells Infected With Rous Sarcoma Virus”,Molecular and Cellular Biology 6(6):2198-2206 (1986).
Bucci L.R. et al., “Isolation and Biochemical Studies Of Enriched Populations Of Spermatogonia And Early Primary Spermatocytes From Rat Testes”,Biology of Reproduction 34:195-206 (1986).
Wozney J.M. et al., “Novel Regulators Of Bone Formation: Molecular Clones And Activities”,Science 242:1528-1534 (1988).
McGuire P.G. et al., “The Interaction Of Plasminogen Activator With A Reconstituted Basement Membrane Matrix And Extracellular Macromolecules Produced By Cultured Epithelial Cells”,Journal of Cellular Biochemistry 40:215-227 (1989).
Sonnenberg A. et al., “Integrin Recognition Of Different Cell-Binding Fragments Of Laminin (P1, E3, E8) And Evidence That α6β1 But Not α6β4 Functions As A Major Receptor For Fragment E8”,The Journal of Cell Biology 110:2145-2155 (1990).
Ervasti J.M. et al., “A Role For The Dystrophin-Glycoprotein Complex As A Transmembrane Linker Between Laminin And Actin”,The Journal of Cell Biology 122:809-822 (1993).
Vlahos C.J. et al., “A Specific Inhibitor Of Phosphatidylinositol 3-Kinase, 2-(4-Morpholinyl)-8-Phenyl-4H-1-Benzopyran-4-One (LY294002)”,The Journal of Biological Chemistry 269(7):5241-5248 (1994).
Powis G. et al., “Wortmannin, A Potent And Selective Inhibitor Of Phosphatidylinositol-3-Kinase”,Cancer Research 54:2419-2423 (1994).
Vukicevic S. et al., “Localization Of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) During Human Embryonic Development: High Affinity Binding To Basement Membranes”,Biochemical and Biophysical Research Communications 198(2): 693-700 (1994).
Jonsson J. et al., “Insulin-Promoter-Factor 1 Is Required For Pancreas Development In Mice”,Nature 371:606-609 (1994).
Katagiri T. et al., “Bone Morphogenetic Protein-2 Converts The Differentiation Pathway Of C2C12 Myoblasts Into The Osteoblast Lineage”,The Journal of Cell Biology 127(6):1755-1766 (1994).
Streuli C.H. et al., “Laminin Mediates Tissue-Specific Gene Expression In Mammary Epithelia”,The Journal of Cell Biology 129:591-603 (1995).
Winnier G. et al., “Bone Morphogenetic Protein-4 Is Required For Mesoderm Formation And Patterning In The Mouse”,Genes&Development 9:2105-2116 (1995).
Slack J.M.W., “Development Biology Of The Pancreas”,Development 121:1569-1580 (1995).
Durbeej M. et al., “Non-Muscle α—Dystroglycan Is Involved In Epithelial Development”,The Journal of Cell Biology 130(1):79-91 (1995).
Dudley D.T. et al., “A Synthetic Inhibitor Of The Mitogen-Activated Protein Kinase Cascade”,Proc. Natl. Acad. Sci. USA 92:7686-7689 (1995).
Dudley A.T. et al., “A Requirement For Bone Morphogenetic Protein-7 During Development Of The Mammalian Kidney And Eye”,GenesandDevelopment 9:2795-2807 (1995).
Almeida E.A.C. et al., “Mouse Egg Integrin α6β1 Functions As A Sperm Receptor”,Cell 81:1095-1104 (1995).
Lyons K.M. et al., “Colocalization of BMP 7 And BMP 2 RNAs Suggests That These Factors Cooperatively Mediate Tissue Interactions During Murine Development”,Mechanisms of Development 50:71-83 (1995).
Luo G. et al., “BMP-7 Is An Inducer of Nephrogenesis, And Is Also Required For Eye Development And Skeletal Patterning”,Genes&Development 9:2808-2820 (1995).
Aono A. et al., “Potent Ectopic Bone-Inducing Activity Of Bone Morphogenetic Protein-4/7 Heterodimer”,Biochemical&Biophysical Research Communication 210(3):670-677 (1995).
Hogan B.LM., “Bone Morphogenetic Proteins In Development”,Current Opinion in Genetics&Development 6:432-438 (1996).
Kerr-Conte J. et al., “Ductal Cyst Formation In Collagen-Embedded Adult Human Islet Preparations-A Means To The Reproduction Of Nesidioblastosis In Vitro”,Diabetes 45:1108-1114 (1996).
Schuger L. et al., “Laminin And Heparan Sulfate Proteoglycan Mediate Epithelial Cell Polarization In Organotypic Cultures Of Embryonic Lung Cells: Evidence Implicating Involvement Of The Inner Globular Region Of Laminin β1 Chain And The Heparan Sulfate Groups Of Heparan Sulfate Proteoglycan”,Development Biology 179:264-273 (1996).
Yuan S. et al., “Transdifferentiation Of Human Islets To Pancreatic Ductal Cells In Collagen Matrix Culture”,Differentiation 61:67-75 (1996).
Zhang H. et al., “Mice Deficient For BMP2 Are Nonviable And Have Defects In Amnion/Chorion And Cardiac Development”,Development 122:2977-2986 (1996).
Pall E.A. et al., “Differential Heparin Inhibition Of Skeletal Muscle α-Dystroglycan Binding To Laminins”,The Journal of Biological Chemistry 271(7):3817-3821 (1996).
Offield M.F. et al., “PDX-1 Is Required For Pancreatic Outgrowth And Differentiation Of The Rostral Duodenum”,Development 122:983-995 (1996).
Lelievre S. et al., “Extracellular Matrix Signaling From The Cellular Membrane Skeleton To The Nuclear Skeleton: A Model Of Gene Regulation”,Recent Progress in Hormone Research 51:417-432 (1996).
Georges-Labouesse E. et al., “Absence Of Integrin α6 Leads To Epidermolysis Bullosa And Neonatal Death In Mice”,Nature Genetics 13:370-373 (1996).
Gao Z-Y. et al., “Wortmannin Inhibits Insulin Secretion In Pancreatic Islets And β—TC3 Cells Independent Of Its Inhibition Of Phosphatidylinositol 3-Kinase”,Diabetes 45:854-862 (1996).
Frade J.M. et al., “Laminin-1 Selectively Stimulates Neuron Generation From Cultured Retinal Neuroepithelial Cells”,Experimental Cell Research 222:140-149 (1996).
Ekblom P., “Receptors For Laminins During Epithelial Morphogenesis”,Current Opinion in Cell Biology 8:700-706 (1996).
Falk M. et al., “Integrin α 6Bβ1 Is Involved In Kidney Tubulogenesis In Vitro”,Journal of Cell Science 109:2801-2810 (1996).
Bottinger E.P. et al.,

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