Pancreatic islet cell antigens obtained by molecular cloning

Details Pancreatic islet cell antigens obtained by molecular cloning Pancreatic islet cell antigens obtained by molecular cloning

1994-05-05

1998-11-24

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530376, 530350, C07K 14705

Patent

active

058408363

ABSTRACT:
Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cells. Full sequence native ICA proteins, or protein or peptide fragments thereof, can be used in the diagnosis of IDDM and in detecting or blocking human immunoglobulin, T-cells, or B-cells involved in IDDM.

REFERENCES:
patent: 5200318 (1993-04-01), Rabin et al.
Srikanta et al. (1986) Mol. Biol. Med 3:113-127.
Karounos et al. (1988) Diabetes 37(5) :30A.
Moncayo et al. (1988) Diabetologia 31(7) :523A.
Glover (1984) "Principles of Cloning DNA" Gene Cloning pp. 1-19.

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