Pancreatic islet cell antigens obtained by molecular cloning

Details Pancreatic islet cell antigens obtained by molecular cloning Pancreatic islet cell antigens obtained by molecular cloning

1995-06-06

1999-11-09

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 530331, 536 231, C07K 1400

Patent

active

059817003

ABSTRACT:
Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cells. Full sequence native ICA proteins, or protein or peptide fragments thereof, can be used in the diagnosis of IDDM and in detecting or blocking human immunoglobulin, T-cells, or B-cells involved in IDDM.

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