Pancreatic islet cell antigens obtained by molecular cloning

Details Pancreatic islet cell antigens obtained by molecular cloning Pancreatic islet cell antigens obtained by molecular cloning

1995-06-06

1999-12-14

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 71, 4352523, 4353201, 536 231, 530350, 530300, A61K 6700, C12Q 100, C07H 1700, C07K 1400

Patent

active

060018046

ABSTRACT:
Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cells. Full sequence native ICA proteins, or protein or peptide fragments thereof, can be used in the diagnosis of IDDM and in detecting or blocking human immunoglobulin, T-cells, or B-cells involved in IDDM.

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