Pancreatic imaging agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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546229, 546232, 548561, C07D26530, C07D21126, C07D20730

Patent

active

053490630

ABSTRACT:
A novel group of radiolabelled diamines are provided, effective for pancreatic imaging and represented by the formula ##STR1## wherein n is 1 to 10; R.sub.1 and R.sub.2 are the same or different and are hydrogen, hydroxyl or lower alkyl having 1 to 6 carbon atoms; R.sub.3 is lower alkyl having 1 to 6 carbon atoms; and N' is a nitrogen atom forming part of a 4- to 8-membered heterocyclic ring containing one or two hetero atoms, one of which is said nitrogen, said heterocyclic ring being unsubstituted or substituted with one or more lower alkyl groups and pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 4360511 (1982-11-01), Baldwin et al.
patent: 4430319 (1984-02-01), Blau et al.
Trampesch et al. Chem. Abstracts, vol. 98, No. 3, 13806x 1983.
"Gastroenterology: Pancreas", No. 558, vol. 27, No. 6, p. 1013 Yamamoto et al., 1986.
"A New Brain Perfusion Imaging Agent: [1-123]HIPDM:N,N,N'-Trimethyl-N'-[2-Hydroxyl-3-Methyl-5-Iodobenzyl]-1,3-Pr opanediamine" Kung et al; The Journal Of Nuclear Medicine; pp. 66-72, 1987.
"Pancreas Accumulation Of Radioiodinated HIPDM in Mice and Rats", Yamamoto et al, vol. 26, No. 7, pp. 765-769, 1985.
"Human Pancreas Scintigraphy Using Iodine-123-Labeled HIPDM and SPECT", Yamamoto et al, pp. 1015.1019, 1989.

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