Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1996-10-16
2000-12-05
Chambers, Jasemine
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
514 44, 4353201, 435325, 435 691, 435455, 435456, 536 231, 536 235, A01N 4304, A61K 3170, C12N 1500, C12N 1563
Patent
active
061563064
ABSTRACT:
The invention provides a cells which express a gene or genes, derived from the adenovirus E3 region, which block allograft rejection. One class of genes blocks the intracellular transport and/or intracellular maturation within the cells of proteins called MHC class I products. Without limitation as to theory, it is believed that blocking the appearance of this class of proteins on the transplanted cell's surface, prevents the host's immune system from rejecting the graft. Another class of proteins acts to permit TNF .alpha.-mediated cell cytolysis. In one embodiment, the invention is directed towards engrafting the cells that secrete insulin, which are called alternatively, pancreatic .beta.-cells and islet cells, and thereby provide a treatment of diabetes mellitus.
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Brownlee Michael
Efrat Shimon
Federoff Howard J.
Horwitz Marshall S.
Albert Einstein College of Medicine of Yeshiva University
Chambers Jasemine
Martin Jill D.
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