Chemistry: analytical and immunological testing – Involving production or treatment of antibody – Monoclonal antibody
Patent
1986-12-01
1988-08-16
Schain, Howard E.
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
Monoclonal antibody
435 7, 424 85, 436817, G01N 33567, G01N 33577, A61K 3704
Patent
active
047644753
ABSTRACT:
A correlation has been demonstrated between the ability of an antibody to block the inhibitory action of somatostatin on the gastric inhibitory peptide(GIP)-stimulated release of insulin from the pancreas in vitro and the ability to stimulate growth in vivo. Antibodies which are identified in the GIP-stimulated insulin release assay are also capable of elevating the levels of growth hormone in vivo.
REFERENCES:
patent: 3995019 (1976-11-01), Jerome
patent: 4185084 (1980-01-01), Mochida et al.
patent: 4599229 (1986-07-01), Maccecchini
McIntosh et al., Chem. Abstracts 94:202973w (for Can. J. Phys. Pharmacol., 59(5), 468, (1981)).
McIntosh et al., Chem. Abstracts, 90:68566c (for Z. Gastroenterol., 16(5), 330, (1970)).
McIntosh et al., Chem. Abstracts, 89:127026f (for Gut Hormone, (1978), 453-6, Bloom (ed)).
Kushan J.
Schain Howard E.
The University of British Columbia
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