Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-01-09
1996-06-25
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
546 23, C07F 9576, A61K 31675
Patent
active
055299890
ABSTRACT:
Pancratistatin has been selected for pre-clinical development but is sparingly soluble in water. A disodium phosphate derivative has been synthesized which is water soluble and is bioequivalent thereof. The critical step in the synthesis of the phenolic phosphate was phosphorylation of 1,2,3,4-tetraacetoxy-pancratistatin with dibenzyloxy(N,N-diisopropylamido)phosphine. This pancratistatin prodrug has the structure set forth below: ##STR1##
REFERENCES:
patent: 4985436 (1991-01-01), Pettit
Medicinal Chemistry, The Role of Organic Chemistry in Drug Research, 2nd tion, 1993, Chapter 4, A. J. Collis, pp. 72-73.
Freeman Sally
Pettit George R.
Arizona Board of Regents acting on behalf of Arizona State Unive
Mybeck Richard R.
Mybeck, II Walter R.
Tsang Cecilia
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