Data processing: structural design – modeling – simulation – and em – Modeling by mathematical expression
Reexamination Certificate
2004-11-05
2009-12-15
Moran, Marjorie (Department: 1631)
Data processing: structural design, modeling, simulation, and em
Modeling by mathematical expression
C703S012000, C702S027000, C427S002180
Reexamination Certificate
active
07634390
ABSTRACT:
A method and computer program product for simulating a pan coating process estimates at least one of tablet coating uniformity or coated tablet weight uniformity for tablets within a tablet bed of a pan. The simulation includes obtaining a plurality of parameters associated with the pan coating process, selecting tablet paths for each cycle of a simulation tablet in the tablet bed, determining a coating amounts for the tablet based on selected tablet paths, determining cycle times for the tablet, and summing the determined coating amounts and cycle times for the tablet. The simulation is repeated for each of a defined number of simulation tablets representing the tablets within the tablet bed to determine tablet coating uniformity and/or coated tablet weight uniformity for the tablets. Tablet paths and/or cycle times are determined randomly, e.g., in accordance with a Monte Carlo method.
REFERENCES:
patent: 5211985 (1993-05-01), Shirley, Jr. et al.
patent: 6209259 (2001-04-01), Madigan et al.
patent: 6256597 (2001-07-01), Wang et al.
patent: 6692571 (2004-02-01), Jones et al.
Denis et al. Powder Tech., 2003, 130, 174-180.
Rubinstein, R., Simulation and the Monte Carlo Method, p. 1-19, John Wiley & Sons 1981.
Denis et al., Power Tech., A Model of Surface Renewal with Application to the Coating of Pharmaceutical Tablets in Rotary Drums, 2003, 130, 174-180.
Rubinstein, Systems, Models, Simulation and the Monet Carlo Methods, p. 1-19, John Wiley & Sons, 1981.
Yamane et al., Pharmaceutical Research, Computer Simulation of Tablet Motion in Coating Drum, 1995, 12,1264-1268.
Sandadi et al., Chemical Engineering Science, In Situ, Near Real-time Acquisition of Particle Motion in Rotating Pan Coating Equipment Using Imaging Techniques, 2004, 59, 5807-5817.
Shelukar et al., Identification and characterization of factors controlling tablet coating uniformity in a Wurster coating process, Powder Technology, 2000, 110, 29-36.
Reuven Y. Rubinstein, Simulation and the Monte Carlo Method, pp. 1-19, John Wiley & Sons 1981.
Uzi Mann, Analysis of Spouted-Bed Coating and Granulation. 1. Batch Operation, Ind. Eng. Chem, Process Des. Dev. vol. 22, No. 2, 1983, pp. 288-292.
Michael M.S. Choi and Axel Meisen, Sulphur Coating of Urea in Shallow Spouted Beds, 1995, pp. 1-60.
Cheng et al., “The Prediction of Variability Occurring in Fluidized Bed Coating Equipment. II. The Role of Nonuniform Particle Coverage as Particles Pass Through the Spray Zone”, Pharmaceutical Development and Technology, 5(3), pp. 323-332 (2000).
Choi et al., “Sulfur coating of urea in shallow spouted beds”, Chem. Eng. vol. 52, No. 7, pp. 1073-1086 (1997).
International Search Report for PCT International Application No. PCT/US05/39624 mailed Dec. 15, 2006.
Moran Marjorie
Particle Coating Technology Solutions, Inc.
RatnerPrestia
Riggs, II Larry D
LandOfFree
Pan coating simulation for determining tablet coating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pan coating simulation for determining tablet coating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pan coating simulation for determining tablet coating... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4134571