Pamamycin

Details Pamamycin Pamamycin

1979-07-16

1981-08-11

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3500

Patent

active

042833914

ABSTRACT:
A new antibiotic named pamamycin is derived from S. alboniger. The antibiotic compound is neutral and terpene-like as derived from S. alboniger. The antibiotic is produced in conjunction with substances which either stimulate or inhibit the transition of substrate to aerial mycelia. Pamamycin may be separated by thin layer chromatography. The antibiotic displays particular R.sub.f values in thin layer chromatography as well as a particular antimicrobial spectrum for its use. The molecular formula is 621 and the elemental formula thereof is C.sub.36 H.sub.63 NO.sub.7 as determined by mass spectroscopy. The structure is believed to be a saturated alkane and terpene-like. In vivo tests with Staphylococcus aureus indicate that pamamycin is a potent inhibitor of both DNA and RNA synthesis and this antibiotic has present utility in a 1% solution to degerminate hospital walls.

REFERENCES:
patent: 2763642 (1956-09-01), Porter et al.
McCann et al., Abstracts of Am. Society of Microbiology (1977) p. 176.
Pogell, Third International Symposium on the Genetic of Industrial Microorganism, Madison, Wisconsin, Jun. 4-9, 1978.
McCann et al., J. of Antibiotics, Pamamycin, A New Antibiotic and Stimulator of Aerial Mycelia Formation, vol. 32, No. 7, Jul. 1979, pp. 673-678.

Affiliated with

Also associated with

Rating

Pamamycin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pamamycin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pamamycin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1025804