Palmerolides: methods of preparation and derivatives thereof

Details Palmerolides: methods of preparation and derivatives thereof Palmerolides: methods of preparation and derivatives thereof

2008-04-04

2010-11-23

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07838691

ABSTRACT:
Organic compounds having Formulas I and II are provided where the variables have the values described herein.Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier can be prepared. Methods of preparing the compounds includes deprotecting protected precursor compounds. Methods of treating cancer or inhibiting ATPase include administering the organic compounds to a subject in need thereof.

REFERENCES:
patent: 5552548 (1996-09-01), Quallich
patent: 7625885 (2009-12-01), Baker et al.
patent: 2005/0009765 (2005-01-01), Yu et al.
patent: 2005/0187286 (2005-08-01), Baker et al.
patent: WO 97/41097 (1996-09-01), None
patent: WO 2007/035734 (2007-03-01), None
Diyabalanage et al. J. Am. Chem. Soc., 2006, 128, 5630-5631.
Urbina et al. Biol Res 39: 289-296, 2006.
Wolff, Burger's Medicinal Chemistry and Drug Discovery, vol. 1, Principles and Practice, John Wiley & Sons, New York. 1997.
Chin et al. Drug Discovery From Natural Sources, The AAPS Journal 2006, 8(2), Article 28.
Cragg et al. Natural products in Drug Discovery and Development, J. Natural Products, 1997, 60, 52-60.
Burger's Medical Chemistry and Drug Chemistry 5thed. pp. 172-178 & 949-982, (1995).
Thushara Diyabalanage et al., “Palmerolide A, a Cytotoxic Macrolide from the Antarctic Tunicate Synoicum adareanum”, J. Am. Chem. Soc. 2006, 128, 5630-5631.
Thomas Voets et al., “TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Adsorption”, The Journal of Biological Chemistry vol. 279, No. 1, Issue of Jan. 2, 2004, pp. 19-25.
W. Clark Still et al., “Rapid Chromatographic Technique for Preparative Separations with Moderate Resolution”, J. Org. Chem. vol. 43, No. 14, 1978, 2923-2925.
Shin-ichi Shirokawa et al., “Remote Asymmetric Induction with Vinylketene Silyl N, O-Acetal”, J. Am. Chem. Soc. 2004, 126, 13604-13605.
James A. Marshall et al., “Diastereoselective Additions of Chiral Vinylzinc Reagents to α-Chiral Aldehydes”, Organic Letters, 2004, vol. 6, No. 3, pp. 445-448.
Merek Urbansky et al., “Synthesis of Enantiopure 2-C-Methy-D-erythritol 4-Phosphate and 2,4-Cyclodiphosphate from D-Arabitol”, Organic Letters, vol. 6, No. 1, 2004, 135-138.
Peter G.M. Wuts et al., “Preparation of Halomethaneboronates”, Journal of Organometallic Chemistry, 234 (1982) 137-141.
Marinella Govoni et al., “A Chemical Switch for the Modulation of the functional Activity of Higher Homologues of Histamine on the Human Histamine H3 Receptor: Effect of Various Substitutions at the Primary Amino function”, J. Med. Chem. 2006, 49, 2549-2557.

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